Aluminum Phosphide Poisoning, Mechanism of Action and Treatment: a Literature Review
نویسندگان
چکیده مقاله:
Aluminum phosphide (AlP) is an important fumigant, a commendable and very effective outdoor and indoor insecticide. AlP, locally named “rice tablet”, is widely used to protect rice. As soon as taking a very small amount of an AlP tablet, phosphine vaporizes due to the exposure to the air and affects different kinds of organs. Although, in most cases, clinical history can help making the final diagnosis, analytical tests such as gas chromatographic method in post-mortem specimens and survivors have been developed to measure the level of phosphine and to distinguish between ZnP and AlP poisoning. AlP poisoning management should be started quickly. In addition to supportive therapy, various antioxidant agents, as candidate protective factors, such as N-acetylcysteine (NAC), melatonin, glutathione, magnesium, β-carotene, and vitamin C and E have also been recommended to decrease oxidative damage and cardiotoxicity due to the limited antioxidant defense systems. The present study highlights the fact that Antioxidant therapy in severe ALP poisoning confers different survival benefits. This literature review showed that the administration of antioxidant therapy in addition to the supportive treatment may decrease the mortality rate and could be considered in the treatment of acute AlP poisoning in combination with other therapeutic protocols.
منابع مشابه
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Aluminum phosphide (AlP) as 3 g tablet is widely used in Iran to protect stored food grains from pests. Hyperglycemia following its ingestion has been already reported in the recent years but severe hypoglycemia is uncommon. Here, we report a 19 year old male who attempted suicide with one tablet of AlP and demonstrated severe hypoglycemia. Despite restoration of blood glucose concentration to ...
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عنوان ژورنال
دوره 26 شماره 5
صفحات 406- 419
تاریخ انتشار 2019-09-01
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