گفتمان سال 1395

Bio013508 1395..1399

Fast-start escape responses are critical behaviours used by fishes during predator-prey encounters and some interactions with heteroand conspecifics. In experimental studies, escape responses are often measured once per individual and considered representative of maximum performance. However, few studies have compared variability and repeatability in escape performances within and among individ...

NpgRJ_NN_1987 1395..1397

Instrumental conditioning allows animals to learn about the consequences of their own actions, but the underpinning molecular mechanisms remain elusive. Here we show that the sphingosine-1-phosphate (S1P) receptor Gpr6 is selectively expressed in the striatopallidal neurons in the striatum. Gpr6deficient mice showed reduced striatal cyclic AMP production in vitro and selective alterations in in...

Dev121723 1390..1395

Lysophosphatidic acid (LPA) is a bioactive phospholipid that is present in all tissues examined to date. LPA signals extracellularly via cognate G protein-coupled receptors to mediate cellular processes such as survival, proliferation, differentiation, migration, adhesion and morphology. These LPA-influenced processes impact many aspects of organismaldevelopment. Inparticular, LPAsignallinghasb...

62-67 Cervera LAJP 1395

At present, meprobamate is not a drug with a broad commercial spectrum. In order to get an optimal pharmaceutical formulation for this kind of drug or others more competitive, experimental design methodology is a statistical tool very useful for reach them. The principal aim of this work was to apply D-Optimal mixture design for optimization of meprobamate (400 mg) fast released tablets manufac...

نمایه مقالات سال 1395

Chem. Pharm. Bull. 53(11) 1392—1395 (2005)

or pharmaceutical use of traditional Chinese medicine (TCM) has made it absolutely essential to carry out stringent quality control measures. So far, it is widely accepted that multiple constituents are responsible for the therapeutic effects of TCM, and to ensure its quality, therefore, it is necessary to quantitatively determine the multi-bioactive components of TCM. Over the past decades, va...