مطالعه 163 کودک بستری شده با تشخیص اولیه بالینی تب تیفوئیدی سخت در بخش عفونی مرکز طبی کودکان تهران

Invasive salmonellosis is common in tropical areas. This study examines the performance of a clinical definition for its recognition among children ages 1 to 14 years admitting to a referral pediatric hospital in Tehran. 60 children were enrolled into the study during a period of 51 months. To facilitate analysis, cases were divided into 5 categories according to the likelihood of invasive salmonellosis with category A representing microbiologically confirmed salmonella bacteremia 17 (28.3%) and 6 (10%) with positive bone marrow cultures. And category D representing those cases in which an alternative diagnosis was firmly established. Salmonella serology supported invasive salmonellosis as the diagnosis in 17 (28%) of the nonbacteremic children (category B and C). Salmonella serology suggested that invasive salmonellosis without detectable bacteremia was common. Blood culture proved and serologically diagnosed cases shows that the definition has a specificity of at least 60%.