فراوانی کم کاری تیروئید در بیماران دیابتی نوع یک زیر 16 سال

Background and purpose: Diabetes mellitus is the most common endocrinologic disease in children and adolescents. Type 1 diabetes mellitus (T1DM) is frequently associated with autoimmune thyroid disease. It is believed that the prevalence of thyroid disease in T1DM patients is higher than normal population. Various studies reported the incidence of hypothyroidism as 2-32% in T1DM. This study investigated the frequency of hypothyroidism in children with T1DM. Material & methods: In this retrospective study 85 patients with T1DM attending the Endocrine Clinic, 17-Shahrivar Hospital affiliated to Guilan University were recruited. The study was done in 2008-2011. Thyroid function tests including thyroid stimulating hormone (TSH) and thyroxine (T4) were performed. The data including the patients’ age, sex, results of TSH and T4 tests, and duration of disease were obtained. Results: The patients were 40 male (47.1%) and 45 female (52.9%) with the mean age of 9.24±3.57. They were aged 1-15 years old and the mean duration of disease was 18.75±27.36 months. Among the patients seven cases (8.2%) were hypothyroidism (subclinical hypothyroidism). There was no significant association between age, sex, duration of diabetes and hypothyroidism in T1DM patients. Conclusion: Our results demonstrated a high frequency (8.2%) of hypothyroidism in T1DM patients. We suggest regular and annual thyroid function testing in T1DM patients.