تغییرات سطوح سرمی بتاتروفین و بافت پانکراس رت های دیابتی شده با استرپتوزوتوسین به دنبال 4 هفته تمرین استقامتی

Background: Betatrophin known as new therapeutic target of pancreases tissue. The aim of this study was to investigate the effect of endurance training program on betatrophin serum concentrations and pathological changes of  pancreas tissue in diabetic rats. Material and Methods: Male wistar rats (N=24) divided in 3 group include healthy control, diabetic control and endurance training. After induction of diabetes, training group performed 4 weeks endurance training and betatrophin concentration was assessed by ELIZA and The pancreatic tissue was evaluated via histological method.  Results: Results showed that betatrophin serum concentration significantly decreased in diabetic control group (P≤0.05) but there was no significant increases observed in training group (P≥0.05). Compared with diabetic control groups, endurance training didn’t make any significant changes in insulin resistance and beta cell function  (P≥0.05).  In endurance training group, the mean of number and size of pancreatic islets and number of β-cell was higher than diabetic control group. Conclusion: Although endurance training didn’t  able to significantly increase the betatrophin levels but it had a positive effect on the pancreatic tissue in diabetic rats