تأثیر سه الگوی تمرینی روی قدرت عضلانی موش‌های صحرایی مبتلا به پارکینسون القایی با 6-هیدروکسی دوپامین

Background and Aims: Parkinson Disease (PD) as a second neurodegenerative disease has grown in developed and industrial countries due to high life span, and in Iran it is considered an important neurodegenerative disease either. The drug therapy of PD must be paralleled with other treatments because the age of PD occurrence has decreased in recent decades and disturbed active population life styles. The essential approach to PD is pharmacotherapy but alternative treatments were grown recently for alleviating the PD symptoms. The exercise is considered for PD muscular symptoms but the mechanism and effective exercise is not well known. This study was designed to assess the muscle strength in the PD animal model. Material & Methods: The study was conducted on 54 Wistar healthy male rats that were divided into 9 groups with substituable equal number as follows: naïve control, sham-operated, sham-endurance, sham-resistive, sham-combined, PD-control, PD- endurance, PD-resistive, PD-combined. Naïve, PD control and sham-operated had no training but other groups trained with motorized-treadmill and standard ladder for endurance, resistance and combined training. The muscle strength was assessed before and after training by weight lifting test and after the same duration in the untrained groups. PD was induced by intra Substantia Nigra application of 6-hydroxy dopamine. Results: Data analysis showed that the naïve control and sham-operated groups had no changes in the muscle strength but in the trained sham groups the muscle strength increased significantly from 17 to 55% according to training. Although PD-control group had showed lower muscle strength non-significantly, the muscle strength increased up to 32% of PD-control with equal increase. Conclusion: The different training can improve the muscular rehabilitation and neuronal recovery in the animal model of the PD. Although there are some differences in the efficacy of training types in the human cases, it seems that these have non-significant effects in the animals. SOURCE: URMIA MED J 2016: 27(4): 300 ISSN: 1027-3727