بررسی هیستوپاتولوژی و مارکرهای بیولوژی در زنان مبتلا به سرطان پستان قبل از یائسگی (زیر 40 سال) و پس از یائسگی (بالای 60 سال) در بیمارستان رسول اکرم(ص) و آتیه

    Background & Aim: Breast carcinoma is the most common malignant tumor and the leading cause of carcinoma death in women.One of the factors which have been proposed in prognosis and treatment of breast carcinoma is hormonal status and hormonal receptors.  In this study, we investigated histopathology(prognostic factors) and biologic markers(estrogen receptor ER, progesterone receptor PR, P53, HER2/neu and Ki-67) in premenopausal(under 40 years) and postmenopausal(over 60 years) patients with breast cancer who were admitted to Hazrat-e-Rasoul and Atieh hospitals in Tehran.Patients and Method: This analytical cross-sectional study involved 60 cases of premenopausal breast cancer and 57 cases of postmenopausal breast cancer. Immunohistochemistry (IHC) staining was done for ER, PR, P53, HER2/neu and Ki-67 and the results were evaluated by an expert pathologist. All histopathologic data were gathered. The results were analyzed by SPSS v.12 software, Students' t-test, and Chi-square test.Results: There were no significant differences between tumor size, lymph node, histologic grade, stage, ER, PR and HER2/neu in both groups. Ki-67 was high in premenopausal group, but not significant. P53 incidence was significantly higher in premenopausal group (Chi2 value=4.35, P=0.037).Conclusion: This study did not prove the differences in histopathologic factors between pre and post menopausal groups of breast cancer. Hormone dependency of this cancer did not show any significant difference between those two groups. HER2/neu is an independent prognostic factor in cancer outcome prediction. High incidence of Ki-67 and significantly high incidence of P53 in premenopausal patients with breast cancer may reflect some etiologic differences between early and late onset of breast cancer.