بررسی مکمل یاری پودر زنجبیل بر روی پروفایل لیپیدی در بیماران مبتلا به آرتریت رماتوئید

Background: Lipid disorders are the considerable cause and main reason for development of cardiovascular and atherosclerotic disease in rheumatoid arthritis patients. Ginger has the anti-inflammatory and hypolipidemic effect. This study was conducted to evaluate the effect of Ginger powder on lipid profile in rheumatoid arthritis patients. Methods: A randomized, double-blind, placebo-controlled clinical trial was conducted on 72 rheumatoid arthritis referred to rheumatologic clinic of Urmia Emam Khomeini Hospital. Patients were divided randomly into 2 groups, intervention group (receiving ginger tablet 1.5 gr/day) and placebo group (placebo tablet 1.5 gr/day) for 8 weeks. Lipid profile before and after intervention was compared within groups using paired t-test and the mean differences using independent t-test between two groups. Results: At the end of the intervention period, 67 (93.06%) of patients were analyzed. The study showed that in the ginger group, mean of LDL-C decreased after intervention (104.22&plusmn;20.60) in comparison to before (115.19&plusmn;24.86) and mean of HDL-C increased (50.21&plusmn;10.16 at before and 55.27&plusmn;10.19 after the intervention) significantly (p<0.001). In placebo group, mean of LDL-C (113.86&plusmn;19.19 at before and 118.88&plusmn;22.38 after the intervention), TG (134.09&plusmn;59.70 at before and 143.97&plusmn;57.21 after the intervention) and total cholesterol (190.12&plusmn;26.90 at before and 199.17&plusmn;32.50 after the intervention) increased significantly (p<0.05). Mean changes of LDL-C, HDL-C and total cholesterol after intervention was significant between two groups (p<0.05). Mean of TG in ginger group in comparison to placebo group increased slightly but it&rsquo;s changes after was not significant between groups (p=0.36). Conclusion: Current study showed that ginger powder compared to placebo has the ability to modify lipid profile in patients with rheumatoid arthritis.