بررسی لیپیدها و لیپوپروتئین های سرم بیماران مبتلا به پسوریازیس

Background and purpose: Psoriasis is a common chronic and recurrent inflammatory skin disorder characterized by hyper proliferation of keratinocytes and infiltration of T cells, monocytes/macrophages and neutrophils to dermis and epidermis. Prevalence of cardiovascular disorders is remarkable in patients with psoriasis compared to normal individuals. Psoriasis is believed to have associations with hyperlipidemia. This study was designed to investigate the serum lipid profile in psoriatic patients and its association with the severity of disease. Materials and methods: In this case-control study 50 plaque type psoriasis patients and 50 healthy controls were evaluated in Mazandaran University of Medical Sciences, 2012. The blood samples were collected after 14 h in fasting condition. The serum triglyceride, cholesterol and lipoproteins were assayed using a standard kit. Results: Some parameters including serum triglyceride, cholesterol, low density lipoprotein (LDL), and very low density lipoprotein (VLDLS) level were significantly higher in the case group (P<0.001). The high density lipoprotein (HDL) level was significantly lower in the case group (P<0.001). We found a significant relationship between severity of psoriasis and serum lipid profile level. Conclusion: Results revealed higher plasma level of lipid profile in psoriatic patients. Therefore, to decrease the risk of cardiovascular disease monitoring the serum lipid profile level is necessary in psoriatic patients.