بررسی سرولوژی توکسوپلاسموزیس در خانم های معرفی شده جهت انجام آزمایشات قبل از ازدواج در استان مازندران در سال 1378

Background and Purpose: Toxoplasmosis has world wide distribution and in Ïran it’s prevalence is high. Pregnant women infected with Toxoplasma gondii may be prone to abortion, foetal death, still birth or congenital Toxoplasmosis. Ïf we know the percentage of immune women, who are going to get married, we can determine the occurance of abortion, still birth and foetal death due to Toxoplasmosis and congenital Toxoplasmosis. Materials and Methods: Women who are going to get married and referred to the health center laboratory of different cities of Mazandaran state were studied. The samples comprised of 980 women from Sari, Ghaemshahr, Babol, Noshahr, Noor and Behshahr. Five ml blood was drawn, serum was seprated and examined for antibody against Toxoplasmosis by indirect immunofluorescence. First of all, 1/50 titer dilution was tested in the cases of positive result, further dilution was prepared and the last positive dilution was recorded. Results: Serum of 731 samples (75.6%) were positive for Toxoplasma antibody. The confidence interval was 2.7 (74.6 ± 2.7). Most of the samples (37% and 24%) were positive in 1/200 and 1/100 dilutions. With increase in the age of women, percentage of positive cases increased (87.9% of the women with age of 30-34 years were positive for toxoplasma antibody). 96.3% of uneducated women were positive for Toxoplasma antibody. No difference between women in urban and rural areas, also between employed and unemployed women were found. Çonclusion: Toxoplasma infection is more prevalent in Mazandaran state than the other states of country. Since the prevalence rates of Toxoplasmosis are high in women before marriage, we can conuclude that the risk of abortion, still birth and foetal death due to Toxoplasmosis and also congenital Toxoplasmosis in this state is low. Therefore a health recommendation will prevent the risk of Toxoplasmosis in women who are going to marry.