بررسی تاثیر دما و رطوبت بر خصوصیات فیزیکی و رهش Precirol کاربامازپین از پایه پلی اتیلن گلایکول و

Background and purpose: Solubility plays an important role in bioavailability of drugs. Any alter can cause changes in the physical and chemical properties of the drug release and consequently, changes in the bioavailability of the drug. It is necessary to recognize the best storage conditions to achieve desired drug release. Material and Methods: Carbamazepine tablets containing different ratios of polyethylene glycol and Precirol were prepared by direct compression method. The tablets were then placed in various temperatures and humidity for 6 months. Carbamazepine release was investigated from formulations and the data was processed with kinetic models. DSC and FTIR method was used to determine the physical stability of tablets. Results: The results of drug release from various formulations at zero time, 3 and 6 months showed significant differences in formulations containing PEG. The thermogram did not show any interaction between drug and excipients. Conclusion: Statistical studies of dissolution data revealed that storing carbamazepine tablets in different situations can cause significant changes in drug release profile. No changes were observed in the physical stability of the tablets.