بررسی اثر کلروکین بر سیکل استروس و هورمونهای محرک فولیکولی و جسم زرد در موشهای صحرائی ماده

ABSTRACT In this research effect of chloroquine on oestrus cycle,(Follicle Stimuloting Hormone)FSH and (Luteinizing Hormone) LH has been evaluated. There were three groups. Group I (control rats) received an equal volume of physiological salin. Group II animals had chloroquine (25 mg/kg) administered intraperitoneally (I.P) for 3 days and group III animals received chloroquine 30 mgkg for ten days. Oestrus cycle was monitored by daily saline vaginal lavage. All animals were sacrificed at the treatment. Trunk blood was collected in each group at the time of sacrifice, centrifuged and serum stored for subsequent ratio immunoassay of luteinizing hormone (LH) and follicle stimulating hormone (FSH). Results showed that administration of chloroquine (25 mg/kg) did not affect on oestrus cycle and gonadotropins, but 30 mg/kg chloroquine for ten days showed a persistent dioestrus in 62% of rats, lowered serum LH levels (P<0.05) while serum FSH was unaltered. This study support the notion that chloroquine had an adverse effect on hypothalamo-pituitary ovarian systems.