بررسی اثر پیشگیری کننده افدرین در کاهش وقوع افت فشار خون در بی حسی نخاعی

         In a double blind controlled, randomized clinical trial study,we have     investigated  the  efficacy of I.M  ephedrine in 100  patients undergoing     surgery under spinal anaesthesia to level T.          Fifty patients recieved ephedrine 0.5mg kg(2cc)in deltoid muscle of    right  arm  just  before  spinal  anaesthesia.  Fifty  patients  recieved equal    volume of disttiled  water (2cc).  Patients in  both groups  were  given the    same volumes  of N/S (10 . kg ).          Mean   arterial   pressure  during   the   first  60  min  after  anaesthesia    remained significantly more stable  in the  ephedrine group (P= 0.000002)    and the  incidence  of  hypotension lower than base MAP was very lower    than  placebo group(2% versus 40% and P=0.000009).          We concluded  that   0.5   mg. kg ephedrine  I.M  just  before  spinal    anaesthesia is a simple  and  effective  means of reducing  the incidence    of hypotension episode after spinal anaesthesia.