ارتباط پلی‌مورفیسم M55Vژن SUMO4 در بیماران دیابتی تیپ 2 و افراد سالم

    Background & Aim: Sumo4 has recently been found to be mainly expressed in kidney. Single nucleotide polymorphism, which is detected in sumo4, replaces a highly conserved methionine with a valine (M55V) residue. This variant of sumo4 may induce higher nuclear factor–KB (NFKB) activity because NFKB is known to mediate the development of diabetic nephropathy.Patients and Method: This study involved 50 patients with type 2 diabetes and 50 healthy subjects. The M55V polymorphism of sumo4 was genotyped by PCR and restriction enzyme digestion. The serum glucose concentration was measured by enzymatic method. Students' t-test and Chi-square test were used to analyze the data.Results: The frequency of sumo4 AA, GA and GG was 20%, 44% and 36% in the case group and 26%, 50% and 24% in the control group respectively. Conclusion: The results suggest that the sumo4 M55V variant is not associated with type 2 diabetes mellitus susceptibility, suggesting that it may not be involved in the pathogenesis of type 2 diabetes.