رامین صادقی
دانشیار مرکز تحقیقات پزشکی هسته ای بیمارستان امام رضا، دانشگاه علوم پزشکی مشهد، ایران
[ 1 ] - مرور نظام مند و متاآنالیز در مورد بررسی اثر بارگذاری فوری ایمپلنتهای کاشته شده در حفره دندانهای تازه کشیده شده بر موفقیت ایمپلنت
مقدمه:هدف از این مطالعه تعیین اثر بارگذاری فوری ایمپلنتهای کاشته شده در حفره دندانهای تازه کشیده شده بر موفقیت کلینیکی ایمپلنت با جمع آوری، ارزیابی و مرور نظام مند مقالات مرتبط با این موضوع میباشد. مواد و روشها: در این مطالعه جستجو در بانکهای اطلاعاتی Pubmed, Scopus و ISI (Web of science) انجام شد. و با توجه به کلمات کلیدی انتخاب شده، کلیه مقالاتی که تا 22 اکتبر 2013 در این بانکها ایندک...
[ 2 ] - بررسی نتایج بیوپسی غده لنفاوی نگهبان در 110 بیمار با کانسر پستان
مقدمه: سرطان پستان، شایع ترین سرطان در زنان بوده و درمان آن شامل حذف پستان و غدد لنفاوی اگزیلاری است. مطالعه حاضر با هدف بررسی نتایج حاصل از بیوپسی غده لنفاوی نگهبان در بیماران مبتلا به سرطان پستان انجام شد. روش‌کار: این مطالعه گذشته نگر طی سال های 88-1386 بر روی 110 بیمار مبتلا به سرطان پستان مرحله اول و دوم در بیمارستان امید وابسته به دانشگاه علوم پزشکی مشهد انجام شد. افراد تحت بررسی غدد لنف...
[ 3 ] - Comparison of Treatment Response Achieved by Tablet Splitting Versus Whole Tablet Administration of Levothyroxine in Patients with Thyroid Cancer
Objective(s): TSH suppression by Levothyroxine consumption is a mainstay of thyroid cancer treatment. Tablet-splitting is a worldwide approach in dose adjustment in patients. However, it is highly recommended to evaluate the validity of tablet splitting for each distinctive drug by clinical trials before routinely using tablet halves in clinical practice. In this study we compared the effect of...
[ 4 ] - Sagliker Syndrome in a Patient with Secondary Hyperparathyroidism and Chronic Renal Insufficiency: A Case Report
Sagliker syndrome is a rare form of renal osteodystrophy resulted from untreated secondary hyperparathyroidism. It is described by severe skeletal deformities, high level of PTH in patients with chronic renal failure, and deformed face. This paper reports a 44-year-old male patient with the mentioned characteristics. In addition to the unique clinical features, high levels of ALP and PTH hormon...
[ 5 ] - Assessment of Ultrasound / Radio-guided Occult Lesion Localization in Non-palpable Breast Lesions
Objective(s): Controversy exists about the localization of non-palpable breast lesions. In many countries, the gold standard for the diagnosis of these lesions is needle localization due to its accuracy. This study sought to compare the ultrasoundand radio-guided occult lesion localization (ROLL) as a simple method with the conventional procedures in terms of their diagnostic power. Methods: Th...
[ 6 ] - 99mTc-TRODAT-1 SPECT Imaging in Early and Late Onset Parkinson’s Disease
Objective(s): 99mTc-TRODAT-1, which binds to the dopamine transporter, could be used to image the dopaminergic system in diagnosis of Parkinson’s disease (PD). PD can be classified into two groups: late onset Parkinson’s disease (LOPD) and early onset Parkinson’s disease (EOPD). In this study we tried to determine the TRODAT SPECT findings in EOPD as compared to LOPD.Methods: Fifteen patients w...
[ 7 ] - Inappropriate cervical injection of radiotracer for sentinel node mapping in a uterine cervix cancer patient: importance of lymphoscintigraphy and blue dye injection
Herein, we report a case of sentinel lymph node mapping in a uterine cervix cancer patient, referring to the nuclear medicine department of our institute. Lymphoscintigraphy images showed inappropriate intra‐cervical injection of radiotracer. Blue dye technique was applied for sentinel lymph node mapping, using intra‐cervical injection of methylene blue. Two blue/cold sentinel lymph nodes, with...
[ 8 ] - Is Tc99m-MIBI scintigraphy a predictor of response to pre-operative neoadjuvant chemotherapy in Osteosarcoma?
Objectives: Multidrug resistance (MDR), which may be due to the over expression of P-glycoprotein (Pgp) and/or MRP, is a major problem in neoadjuvant chemotherapy of osteosarcoma. The aim of this study was to investigate the role of Tc-99m MIBI scan for predicting the response to pre-operative chemotherapy. Materials and Methods: Twenty-five patients (12 males and 13 females, aged between 8 and...
[ 9 ] - Clinical value and severity of myocardial perfusion defects in asymptomatic diabetic patients with negative or weakly positive exercise treadmill test
Objective: Although coronary artery disease (CAD) is the leading cause of death in type 2 diabetic patients, it is frequently asymptomatic. Myocardial perfusion imaging (MPI) is reported to show ischemia in a significant number of asymptomatic diabetic patients. We studied the prevalence and severity of myocardial perfusion defects in asymptomatic diabetic patients and its clinical impact. Meth...
[ 10 ] - A systematic review and meta-analysis of clinical trials on saffron (Crocus sativus) effectiveness and safety on erectile dysfunction and semen parameters
Objective: We performed this systematic review and meta-analysis study to determine saffron (Crocus sativus) effectiveness and safety in male infertility problems. Materials and Methods: The databases PubMed, Scopus, Cochrane, Google Scholar, SID, IranMedex and Magiran until July 2016 and reference section of relevant articles, were searched to find both English and Persian clinical trials on m...
[ 11 ] - Effects of flaxseed and Hypericum perforatum on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women: a systematic review and meta-analysis
Objective: In this study, we aimed at evaluation of the efficacy of Hypericum perforatum and flaxseed on hot flash, vaginal atrophy and estrogen-dependent cancers in menopausal women Materials and Methods: We searched MEDLINE, Scopus, and the Cochrane Central Register of Controlled Trials (RCT) to explore trials that assessed the effectiveness of H. perforatum and flaxseed on hot flash, vagina...
[ 12 ] - Effects of red clover on hot flash and circulating hormone concentrations in menopausal women: a systematic review and meta-analysis
Objectives: To critically evaluate the effect of red clover on hot flash, endometrial thickness, and hormones status in postmenopausal and peri- and post-menopausal women. Materials and Methods: MEDLINE (1966 to July 2014), Scopus (1990 to July 2014), and the Cochrane Central Register of Controlled Trials (The Cochrane Library issue 1, 2014) were searched for published randomized controlled Tri...
[ 13 ] - Citation Analysis of Iranian Journal of Basic Medical Sciences in ISI Web of Knowledge, Scopus, and Google Scholar
Objective(s): Citation tracking is an important method to analyze the scientific impact of journal articles and can be done through Scopus (SC), Google Scholar (GS), or ISI web of knowledge (WOS). In the current study, we analyzed the citations to 2011-2012 articles of Iranian Journal of Basic Medical Sciences (IJBMS) in these three resources. Material and Methods: The rel...
[ 14 ] - Publication Ethics: A Case Series with Recommendations According to Committee on Publication Ethics (COPE)
Ethical misconduct is not a new issue in the history of science and literature. However, ethical misconducts in science have grown considerably in the modern era which is due to emphasis on the scientific proliferation in research institutes and gauging scientists according to their publications. In the current case series, several misconducts occurring over the previous years in Mashhad Univer...
[ 15 ] - Image Optimization in Single Photon Emission Computed Tomography by Hardware Modifications with Monte Carlo Simulation
Introduction: In Single Photon Emission Computed Tomography (SPECT), the projection data used for image reconstruction are distorted by several factors, including attenuation and scattering of gamma rays, collimator structure, data acquisition method, organ motion, and washout of radiopharmaceuticals. All these make reconstruction of a quantitative SPECT image very difficult. Simulation of a SP...
[ 16 ] - Time frame of sentinel node visualization in early breast cancer patients using intradermal injection of Tc-99m phytate: Imaging beyond 45 minutes does not yield more information
Introduction: One of the major problems of lymphoscintigraphy is the time of patient presence in the nuclear medicine wards. The operating room schedule can be compromised if the patients stay longer than usual in the nuclear medicine departments. However, too early imaging can be falsely negative for sentinel node visualization and delayed imaging may be required. The aim of t...
[ 17 ] - A wandering spleen detected by 99mTc-denatured RBC scan
A 23 day old infant patient underwent 99mTc-denatured RBC scanning for locating possible ectopic spleen in our department. The scan showed no tracer activity in normal splenic bed in the left upper quadrant and an ectopic spleen was shown on the right side of abdomen inferior to the liver. 99mTc-denatured RBC scan is an easy and available method for splenic localization i...
[ 18 ] - False positive lower limb lymphoscintigraphy due to inadvertent intra-vascular injection of the tracer: Importance of tracer re-injection
We presented a 30 year-old woman presented with symmetrical swelling of the lower limbs since 5 years ago with sparing of the feet. She was highly suspicious of having lipoedema and was referred for lower limb lymphoscintigraphy to rule out possible lymphedema. Lymphoscintigraphy images showed asymmetrical injection sites and unusually high liver and spleen uptake. Inguinal nodes was not visual...
[ 19 ] - Nicorandil effect on myocardial perfusion in patients with slow coronary flow phenomenon assessment by gated myocardial perfusion SPECT
Introduction:Patients with the coronary slow flow phenomenon (SCF) frequently experience angina episodes. The purpose of this study was to determine efficacy of nicorandil in myocardial perfusion in patients with SCF. Methods: Twenty patients (50.85 ± 12.96 y) with SCF were studied. We evaluate coronary slow flow according to protracted thrombolysis in m...
[ 20 ] - Radiotracer re-injection in case of sentinel node non-visualization in a breast cancer patient
We reported a 35 year old breast cancer patient who was referred to our nuclear medicine department for sentinel node mapping. She was planned to undergo mastectomy and lymphatic mapping. A dose of Tc-99m Phytate was injection in the peri-areolar region in an intra-dermal fashion. Two hours post-injection no sentinel node was visible in the axilla. Due to a high liver uptake, inadvertent intra-...
[ 21 ] - Dynamic lymphoscintigraphy in breast cancer patients: feasibility and added value
Introduction: Lymphoscintigraphy is imaging of the lymphatic system and has been integrated into the sentinel node mapping procedures. Lymphoscintigraphy usually encompasses early or delayed static images. However, immediate dynamic imaging of the lymphatic basins and tumors has also been used as an adjunct lymphoscintigraphy imaging. The aim of this study was ...
[ 22 ] - Tc-99m Phytate lymphoscintigraphy: An excellent method for diagnosis of underlying cause of chylous ascites
We reported a 14 months old boy referred for evaluation of chylous ascites to our nuclear medicine department. Tc-99m Phytate was injected subcutaneously in his calves and whole body images as well as abdominal SPECT were performed. The SPECT images could localize an area of several intestinal lymphangiomata in the abdominal region. The abnormal region was surgically resected and the patient as...
[ 23 ] - The comparison between ultrasonography and 99mTc-DMSA renal scan in estimation of kidney size
Introduction: Renal length measurement is an important diagnostic clue in several urinary tract abnormalities. Although ultra sonography is the most frequent used modality for renal size estimation, renal diameter assessment by 99mTc-DMSA scintigraphy is of great value. By now, pointing to the renal size in the 99mTc-DMSA scintigraphy report has not been recommended by gui...
[ 24 ] - Efficacy of radiosynovectomy in the treatment of chronic knee synovitis: Systematic review and meta-analysis
Introduction: Knee joints are commonly involved with various inflammatory and non- inflammatory rheumatic diseases. Radiosynovectomy is being used as a local therapeutic option to alleviate pain and swelling in involved joints. The present study evaluated the effectiveness of radiosynovectomy for treatment of chronic knee synovitis. Methods: Through a search of Medline and SCOPUS with (Radiosy...
[ 25 ] - Google Scholar journal metrics: Comparison with impact factor and SCImago journal rank indicator for nuclear medicine journals
Introduction: In the current study, we compared h5-index provided by Google Scholar (GS), impact factor (IF) provided by web of sciences (WOS), and SCImago journal rank indicator (SJR) provided by SCOPUS for quality assessment of nuclear medicine journals. Methods: 2013 h5-index, 2012 IF, and 2011 SJR of nuclear medicine journals were extracted from their publishers namely GS, WOS, and SCOPUS....
[ 26 ] - Which complaint has the most clinical effect on quality of life of thyroid cancer survivors in long term follow up?
Introduction: Differentiated thyroid cancer (DTC) is the most common endocrine malignancy. This malignancy generally has an excellent prognosis with more than 90% long term survival. Consequently, life quality improvement is the first priority especially in the young DTC survivors. In classic management of a new DTC patient, each therapeutic modality can significantly induce morbidities. In the...
[ 27 ] - The value of lateral lymphoscintigraphy images of the pelvis for gynecological cancers: Are they necessary?
Introduction: In the current study we evaluated the incremental value of lateral pelvic lymphoscintigraphy imaging of endometrial or cervical cancer patients who underwent sentinel node mapping. Methods: Operable endometrial and cervical cancer patients without clinical or paraclinical evidence of lymph node involvement were included in the study. The day before surgery the patients were sent ...
[ 28 ] - Semi-quantitative segmental perfusion scoring in myocardial perfusion SPECT: visual vs. automated analysis
Introduction: It is recommended that the physician apply at least a semi-quantitative segmental scoring system in myocardial perfusion SPECT. We aimed to assess the agreement between automated semi-quantitative analysis using QPS (quantitative Perfusion SPECT) software and visual approach for calculation of summed stress score (SSS), summed rest score (SRS) and summed difference score (SDS). ...
[ 29 ] - Sentinel node mapping in vulvar cancers: report of two cases and literature review
Vulvar cancer is a rare gynecological malignancy with mainly lymphatic spread. Sentinel node mapping plays an important role in the management of this gynecological malignancy. In the current study, we reported our experience in sentinel node mapping of vulvar cancer and review the literature accordingly. Since the introduction of sentinel node mapping to the surgical oncology community of our ...
[ 30 ] - Gated 99mTc-MIBI myocardial perfusion SPECT in patients with right bundle branch block but without evidence of coronary artery disease
Introduction: We aimed to investigate the effect of right bundle branch block (RBBB) on perfusion and functional parameters in dipyridamole stress/rest Tc99m-MIBI gated myocardial perfusion SPECT (GSPECT) which may be helpful in interpretation of myocardial perfusion imaging. Methods: We studied 73 patients with low pre-test likelihood of coronary artery disease in two groups: 38 patients wit...
[ 31 ] - Gated myocardial perfusion SPECT in patients with left bundle block but having low probability of coronary artery disease; as compared to the patients with normal electrocardiogram
Introduction: We aimed to investigate of effect of left bundle branch block (LBBB) on perfusion and functional parameters in dipyridamole Tc99m-MIBI gated myocardial perfusion SPECT which may be helpful in interpretation of myocardial perfusion imaging. Methods: We studied 70 patients with low pre-test probability of coronary artery disease in two groups: 35 patients with LBBB and 35 subject...
[ 32 ] - Comparison of ISI web of knowledge, SCOPUS, and Google Scholar h-indices of Iranian nuclear medicine scientists
Introduction: In the current study, we compared the h-indices of Web of Science (WOS), SCOPUS, and GS of the Iranian nuclear medicine scientists Methods: Full time members of two major nuclear medicine research centers of Iran with more than 5 year of experience (Nuclear Medicine Research Center of Mashhad University of Medical Sciences, and Research Institute for Nuclear Medicine of Tehran Un...
[ 33 ] - Sentinel node mapping for early breast cancer patients using 99mTc-phytate: Single center experience on 165 patients
Introduction: Several radiotracers are being used for sentinel node mapping in patients with breast cancer. In the current study, we reported our experience with 99m-Tc Phytate for sentinel node mapping in Mashhad University of Medical Sciences. Methods: All breast cancer patients who underwent sentinel node mapping using 99m-Tc Phytate were included. All patients received intradermal peri-are...
[ 34 ] - Urinary reflux to the non-functioning previous renal graft
Nuclear medicine imaging is routinely used for evaluation of perfusion and function of the transplanted kidneys. At present, the radiopharmaceutical of choice for this study in our center is Tc 99m-Ec. Complications of the kidney graft are demonstrable in the early and delayed images. One of these complications is vesicoureteral reflux to the graft or to the native kidneys. We present a 27 year...
[ 35 ] - Sentinel node detection failure due to defective labeling and large particle size of Tc-99m antimony sulfide colloid
Introduction: Many radiotracers have been used for sentinel node mapping with acceptable results. The main difference between these radiotracers is the particle size. In the current study, we reported defective labeling of Tc-99m antimony sulfide colloid which resulted in large particle size. Methods: Tc-99m-Antimony sulfide colloid was used for axillary sentinel n...
[ 36 ] - Can gallbladder ejection fraction measured by fatty meal cholescitigraphy diagnose chronic cholecystitis?
Introduction: Despite presence of a body of evidence in support of high accuracy of cholecystokinin cholescintigraphy (CCK-CS) , for diagnosis of chronic cholecystitis(CC) , some authors have claimed that gallbladder ejection fraction (GBEF) has poor predictive diagnostic values. The purpose of this study was to determine if there is any difference in GBEF between...
[ 37 ] - Body outlining using Tc-99m filled flood source for lymphoscintigraphy imaging
Introduction: In the current study, we evaluated the feasibility of body outlining using Tc-99m filled flood source for lymphoscintigraphy imaging. Methods: 80 patients were included in the study. Sentinel node mapping was done using Tc-99m Antimony sulfide colloid. For outlining the body a Tc-99m filled flood source was used which was placed behind or lateral to t...
[ 38 ] - Comparison between early and delayed images of 67Ga scintigraphy for evaluation of recurrent lymphoma
Introduction: Despite widespread use of 67Gallium for lymphoma evaluation, timing of imaging after injection is a matter of controversy and to the extent of our knowledge no direct comparison has been made between early and delayed gallium images. We aimed to compare 24 and 48 hours post injection planar gallium imaging for evaluation of lymphoma recurrence. Methods: 255 pa...
[ 39 ] - Echocardiographic left ventricular functional changes in acute hypothyroidism vs. subclinical hyperthyroidism in patients with differentiated thyroid carcinoma
Introduction: In order to assess echocardiographic left ventricular functional indices in patients with differentiated thyroid carcinoma (DTC), after L-T4 withdrawal (short-term overt hypothyroidism) and during TSH suppressive therapy, we have evaluated cardiac hemodynamics in a single cohort study. Methods: 24 patients with DTC were studied in two phases: 1: at least 4 weeks after L-T4 withd...
[ 40 ] - Effect of evidence based medicine training in the quality of journal clubs: A road to evidence based journal clubs
Introduction: Journal clubs play an important role in teaching Evidence Based Medicine (EBM). Evidence based journal clubs focus on real problems of the group, and set a minimum level of evidence for articles to be presented, and in the end a clinical bottom line is set to be used in the daily clinical practice. In this article, we have explained our experience in r...
[ 41 ] - Cuboid fracture in a toddler discovered on the whole body bone scan: A case report
This report presents a 3.5-year-old boy who was hospitalized for limping. Medical history and physical exams were not suggestive for any definitive diagnosis. Laboratory and radiographic exams did not support any specific diagnosis either. Subsequently bone scan was performed and increased activity in the ankle due to cuboid fracture was incidentally observed.
[ 42 ] - Sentinel lymph node biopsy in melanoma patients: An experience with Tc-99m antimony sulfide colloid
Introduction: Sentinel lymph node biopsy is the standard procedure for lymph node staging in intermediate thickness melanoma. In Iran, this procedure has not been addressed sufficiently. In this study, we report our experience in this area. Methods: Ten consecutive patients with intermediate thickness melanoma where included in our study. 1.5 mCi of Tc-99m antimony...
[ 43 ] - Sensitivity of gallium scintigraphy for evaluation of recurrent lymphoma: Comparison of planar and SPECT imaging
Introduction: Although PET scanning using F-18[FDG] is considered the superior radiotracer for tumnor imaging, Gallium-67 is still in use for some malignancies such as lymphoma and hepatoma. One of the strategies to improve the diagnostic accuracy of Gallium is to perform SPECT which is reported to be more sensitive compared to planar imaging. In this study we compa...
[ 44 ] - Incidental change in photopeak during a dynamic renal scan
Abstract is NOT available
[ 45 ] - Minimally invasive radio-guided surgery for hyperparathyroidism: an experience with Tc-99m Sestamibi
Introduction: Radio-guided parathyroid surgery along with other minimally invasive surgeries constitutes the main surgical treatment procedures for different kinds of hyperparathyroidism. In this article we have reported our experience of radio-guided parathyroid surgery using Tc-99m sestamibi. Methods: Ten patients with hyperparathyroidism included in our study. ...
[ 46 ] - Evidence based medicine in nuclear medicine practice; Part I: Introduction, asking answerable questions and searching for the best evidence
Evidence Based Medicine (EBM) is a new approach to patient management which incorporates best evidence with the clinical expertise of the health care providers. Although this approach has had a rapid growth in many clinical disciplines, its applications in radiology and nuclear medicine has not been addressed sufficiently. In this review EBM is briefly explained...
[ 47 ] - Evidence based medicine in nuclear medicine practice; Part II: Appraising and applying the evidence
As described in the first part of this article, Evidence Based Medicine (EBM) is a growing part of medical practice which emphasizes on the best evidence. Finding this evidence by formulating an answerable question and searching strategies were described in the first part of this review. In this part, appraising the retrieved article (with the main focus on the diag...
[ 48 ] - The need for skin pen marking for sentinel lymph node biopsy: A comparative study
Introduction: There is a consensus in the literature that sentinel lymph node biopsy is the standard procedure for axillary staging in early stage (I and II) breast cancer patients. Usually during lymphoscintigraphy, the location of the sentinel lymph node is marked on the skin by an indelible ink. In this study we evaluated this issue in our patients. Methods: 40 ...
[ 49 ] - Diffuse bilateral breast uptake on the myocardial perfusion SPECT of a nursing female
Bilateral diffuse intense breast uptake was noted in a 40 year old female who was evaluated with Tc-99m sestamibi (MIBI) myocardial perfusion scan for possible ischemia. She was breast feeding her 1.5 year old child. The intense uptake in the breasts was superimposed on the apical and anteroapical regions of the myocardium and caused interpretation problem. We recom...
[ 50 ] - Delayed imaging for detection of Meckel's diverticulum in Tc-99m pertechnetate scintigraphy
Tc-99m pertechnetate scintigraphy is the modality of choice for diagnosis of Meckel's diverticulum. Interpretation of Meckel's scan identifies a focal area of radiopharmaceutical uptake in the anterior abdomen similar to normal gastric mucosa. The activity must be of the same pattern and intensity as gastric uptake. We present a 13-year-old patient with gastrointest...
[ 51 ] - Normal values of left ventricular functional indices in gated 99mTc-MIBI myocardial perfusion SPECT
Introduction: Although left ventricular(LV) function parameters measured by gated myocardial perfusion SPECT (GSPECT) have been validated, experimental data have revealed that the calculated the LV function parameters using GSPECT are affected by patient populations as well as particular acquisition and processing conditions. We tried to determine the normal values ...
[ 52 ] - Persistent sub-diaphragmatic activity on the myocardial perfusion scan with 99mTc-Sestamibi
We present a female patient with atypical chest pain who was referred to our department for ischemia evaluation. 99mTc-MIBI myocardial perfusion scan with dipyridamole stress was performed. Sub-diaphragmatic activity in the hepatic tissue and then in the bowel loops caused severe overlap on the inferior wall even on consecutive delayed images. Dipyridamole stress was repeated for the...
[ 53 ] - Studying the specificity of bone SPECT for differentiating malignant from benign lesions in the vertebral column of the patients with a known primary malignancy [Persian]
Metastatic survey of the patients with known primary malignancies with bone scan is one of the most common studies in nuclear medicine. Unfortunately the conventional planar bone scan has a very low specificity for differentiating benign from malignant lesions especially in the spinal column. In this study, we compared the specificity of SPECT imaging and convention...
[ 54 ] - Reverse redistribution in the myocardial perfusion scan with ²º¹Tl [Persian]
Reverse redistribution pattern is defined as decreased activity in the myocardium in the rest phase of the myocardial perfusion scan in comparison with the stress images. There are many studies concerning the etiology and clinical significant of this phenomenon in nuclear medicine literature. The dominant idea about etiology of reverse redistribution is early wash out of the radiotracer f...
[ 55 ] - Intra-Operative Lymphatic Mapping and Sentinel Node Biopsy in Laryngeal Carcinoma: Preliminary Results
Introduction: Sentinel node mapping has been used for laryngeal carcinoma in several studies, with excellent results thus far.In the current study, we report our preliminary results on sentinel node mapping in laryngeal carcinoma using intra-operative peri-tumoral injection of a radiotracer. Materials and Methods: Patients with biopsy-proven squamous cell carcinoma of the larynx were included...
[ 56 ] - Effects of Phytoestrogens in Alleviating the Menopausal Symptoms: A Systematic Review and Meta-Analysis
The aim of this research was to perform a systematic review of the efficacy of non-hormonal herbal drugs in the treatment of vaginal atrophy in postmenopausal women. Three electronic databases were systematically searched from their inception to May2015: PubMed, Cochrane Library (Cochrane Central Register of Controlled Trials) and Scopus. In this meta-analysis, vaginal maturation value was cons...
[ 57 ] - Nano Liposomes labeled with 99mTc-HMPAO, A Novel Agent for Blood Pool Imaging
In-vitro labeling of RBC with 99mTc is an intricate procedure and there is always a need foran alternate blood pool imaging agent. The aim of this study was to prepare an effective nanosized liposome (NLs) similar to human RBC for blood pool scintigraphy. This study formulatesPEG-NLs and non-PEG-NLs using film method plus high pressure homogenization technique.Biodistribution studies were perfo...
[ 58 ] - The Role of Nuclear Medicine in The Diagnosis and Management of Solitary Pulmonary Nodules
Solitary pulmonary nodule (SPN) is a frequent finding on the chest x-ray and computed tomography. Nuclear medicine techniques play an important role in the diagnosis and management of SPN. In the current review, we briefly will explain the different nuclear medicine modalities in this regard including positron emission tomography (PET) using 18-F-FDG, and 11-C-Methionine, and single photon em...
[ 59 ] - Effects of Acupuncture on Anxiety in Infertile Women: A Systematic Review of the Literature
Background & aim: Stress and anxiety due to waiting for treatment results and uncertainty of treatment success are common problems in infertile women. Acupuncture has been suggested as an effective strategy to relieve anxiety. This study aimed to review the available evidence on the effects of acupuncture on anxiety in infertile women. Methods: This systematic review was conducted via searching...
[ 60 ] - Effects of Phytoestrogens in Alleviating the Menopausal Symptoms: A Systematic Review and Meta-Analysis
The aim of this research was to perform a systematic review of the efficacy of non-hormonal herbal drugs in the treatment of vaginal atrophy in postmenopausal women. Three electronic databases were systematically searched from their inception to May2015: PubMed, Cochrane Library (Cochrane Central Register of Controlled Trials) and Scopus. In this meta-analysis, vaginal maturation value was cons...
[ 61 ] - Nano Liposomes labeled with 99mTc-HMPAO, A Novel Agent for Blood Pool Imaging
In-vitro labeling of RBC with 99mTc is an intricate procedure and there is always a need foran alternate blood pool imaging agent. The aim of this study was to prepare an effective nanosized liposome (NLs) similar to human RBC for blood pool scintigraphy. This study formulatesPEG-NLs and non-PEG-NLs using film method plus high pressure homogenization technique.Biodistribution studies were perfo...
[ 62 ] - Extra-striatal Uptake of 99mTc-TRODAT SPECT in a Cerebral Meningioma: A Case Report
We reported a 71 years old woman, with history of rest and postural tremor, bradykinesia and memory problems. In her dynamic MRI, a contrastenhanced tumor in the cerebellopontine (CP) angle was found which was compatible with a meningioma. 99mTc-TRODAT SPECT showed decreased activity in the left putamen, indicating idiopathic Parkinson disease. There was also a focus of increased activity on th...
[ 63 ] - Sentinel Node Mapping in Non-small Cell Lung Cancer Using an Intraoperative Radiotracer Technique
Objective(s): Lymph node metastases are the most significant prognostic factor in localized non-small cell lung cancer (NSCLC). Identification of the first nodal drainage site (sentinel node) may improve detection of metastatic nodes. Extended surgeries, such as lobectomy or pneumonectomy with lymph node dissection, are among the therapeutic options of higher acceptab...
[ 64 ] - 18FDG PET/CT in pulmonary carcinosarcoma and brain metastasis
Carcinosarcoma is a rare type of cancer that is composed of a mixture of sarcomatous and carcinomatous elements. Pulmonary carcinosarcoma has a 25% five-year survival rate with a prognosis poorer than other non-small cell lung carcinomas. Herein, we report a case of pulmonary carcinosarcoma and its 18F-FDG PET/CT findings. A 61-year-old male patient presented with brain symptoms, including hea...
[ 65 ] - Calcium and vitamin D supplementation effects on metabolic factors, menstrual cycles and follicular responses in women with polycystic ovary syndrome: A systematic review and meta-analysis
Background: Polycystic ovary syndrome (PCOS) is the most popular endocrine disorder in reproductive age with unknown etiology and many comorbidities. This systematic review focused on the effectiveness of calcium and vitamin D (Ca/ Vit.D) supplementation on metabolic factors, menstrual cycles, and follicular responses in PCOS patients. Methods: Relevant studies were identified from the followi...
[ 66 ] - Negative 99mTc-MIBI uptake in a parathyroid carcinoma: A case report
A 34 year old woman with malaise, polyuria and nocturia as well as nausea and vomiting referred to perform a thyroid scan due to right thyroid lobe mass. The scan showed a cold nodule in the right thyroid lobe. Serum calcium of 16.9, serum phosphorus of 1.8 and PTH of 1156 were noticed in laboratory tests. Parathyroid scan with 99mTc-MIBI showed no abnormal tracer activity in the nec...
[ 67 ] - False positive 18F-FDG PET/CT due to active varicella zoster infection in a Hodgkin’s lymphoma patient
We report a case of Hodgkin lymphoma (classic type) referred for response assessment after two cycles of chemotherapy with ABVD regiment. The F-18 fluorodeoxyglucose positron emission tomography (F-18 FDG PET/CT) showed hypermetabolic cutaneous and subcutaneous lesions with a linear pattern in the left arm with significant F-18 fluorodeoxyglucose positron accumulation in associate with left axi...
[ 68 ] - Barriers to integration of behavioral and social sciences in the general medicine curriculum and recommended strategies to overcome them: A systematic review
Introduction: The integration of behavioral and social sciences(BSS) into the curriculum of medical students in order to equipthem with the necessary knowledge, skills and attitudes is anessential issue, emphasized in many researches. Our aim is toinvestigate the barriers to integrate BSS into the general medicinecurriculum as well as the recommended strategies to overcomesuch barriers through ...
[ 69 ] - Platelet-To-Lymphocyte Ratio as a Predictor of No-Reflow after Primary Percutaneous Coronary Intervention in Patients with ST Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis
Introduction: No-reflow increases the complications and mortality rate of primary percutaneous coronary intervention (PCI). Therefore, it is important to identify patients at a higher risk of developing no-reflow. This study aimed to systematically review the prognostic value of the platelet-to-lymphocyte ratio (PLR) to predict no-reflow. Materials and Methods:</s...
[ 70 ] - The Impact of Birth Ball Exercises on Mode of Delivery and Length of Labor: A Systematic Review and Meta-Analysis
Background & aim: Recently, the use of birth ball in childbirth has been widely considered. This review study aimed to critically evaluate the evidence regarding the effect of using the birth ball on the mode of delivery and length of labor. Methods: For the purpose of the study, the articles related to the subj...
[ 71 ] - Molecular imaging approaches in the diagnosis of breast cancer: A systematic review and meta-analysis
Introduction:The accuracy of positron emission tomography with computed tomography (PET/CT), positron emission mammography (PEM), and breast specific-gamma imaging (BSGI) in diagnosing breast cancer has never been systematically assessed, the present systematic review was aimed to address this issue. Methods:PubMed, Scopus and EMBASE were searched for st...
[ 72 ] - Multiple non-malignant iodine uptake in a 131I whole body scan of a patient with papillary thyroid carcinoma: Importance of SPECT/CT
After thyroidectomy in papillary thyroid carcinoma (PTC) patients, whole body radioiodine scan (WBIS) is necessary for localization of any abnormal radioiodine avid lesions. However false-positive radioiodine uptake in WBIS can be problematic. We report a 32 years old female patient with PTC. After thyroidectomy and radioiodine therapy WBIS was performed. In her post therapy WBIS, there were zo...
[ 73 ] - Giant enostosis of spine with increased uptake on planar and SPECT views of bone scan
An enostosis or bone island is a benign bony lesion that is almost diagnosed based on clinical and radiologic defining characteristics. One of the known diagnostic procedures in the evaluation of enostosis is bone scintigraphy. Generally, we don’t expect to see increased uptake by enostosis in the bone scan. Herein we present a 52-year-old lady who was suffering from chronic low back pain that ...
[ 74 ] - Radioiodine avid adenomatous colon polyp in a post-treatment whole body radioiodine scan
A 47 year old female with papillary thyroid carcinoma was referred to our department for post-treatment whole body iodine scanning. The acquired images revealed a focal zone of intense radiotracer uptake in the right lower quadrant of the abdomen. SPECT/CT fused slices showed a focal zone of the radioiodine (131I) uptake in the right colon wall. Colonoscopy revealed a pedunculated po...
[ 75 ] - Inguino-scrotal bladder hernia: an unexpected finding on 68Ga-PSMA PET/CT
Bladder herniation is an uncommon condition mimicking suspicious metastasis on PET/CT imaging. We report a 67 y/o man with prostate cancer referred for recurrence evaluation with 68Ga-PSMA-11 PET/CT. The scan showed an asymmetric site of intense tracer accumulation in the left inguino-scrotal region with the same SUVmax to the pelvic bladder. Reviewing cross sectional CT i...
[ 76 ] - Spurious lung perfusion ventilation defect on planar ventilation-perfusion scan detected by SPECT imaging
Pulmonary embolism (PE) is a preventable cause of morbidity and mortality which needs prompt recognition. Ventilation-perfusion (V/Q) scan is a well-established diagnostic test for evaluation of suspected PE. We report a 32-year-old woman with history of rheumatologic disease and acute dyspnea, who was referred for V/Q scintigraphy. The planar images revealed multiple mismatched defects through...
[ 77 ] - Extra osseous uptake of 99mTc-MDP in psoas muscle on bone scintigraphy: Importance of SPECT/CT imaging
Incidental extra-osseous uptake of 99mTc-MDP on bone scintigraphy has been frequently reported in the literature; however, calcification of the psoas muscle is a rare condition, which has been reported on magnetic resonance (MR) and computed tomography (CT) imagings. Here we report a 67-year-old woman with acute paraplegia and low back pain who was referred for a 99mTc-MDP...
[ 78 ] - Feasibility of sentinel lymph node mapping in renal cell carcinoma using intraoperative radiotracer injection
Introduction: The applicability of sentinel lymph node biopsy for early detection of metastasis in patients with renal cell carcinoma (RCC) is still in the validation phase and under investigation, which might be due to the unpredictability of the lymphatic pattern in RCC. In this study, we aimed to evaluate the feasibility and accuracy of sentinel node biopsy in patients with ...
[ 79 ] - Atypical non-[99mTc]Tc-MIBI avid parathyroid adenoma with a sternal brown tumor, mimicking ectopic parathyroid adenoma in planar and SPECT images: Importance of SPECT/CT acquisition
Primary hyperparathyroidism (pHPT) is defined by the excess level of parathyroid hormone (PTH). Parathyroid adenoma is responsible for about 80% of all pHPT. Parathyroid adenoma with cystic feature and atypical pathology is recognized as a rare entity. Technetium-99m methoxy isobutyl isonitrile ([99mTc]Tc-MIBI) scintigraphy has favorable detection rate for ectopic gland as well as th...
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