Amir Farshchi
School of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran|Department of Pharmacoeconomics and Pharmaceutical administration, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran|Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
[ 1 ] - The Effect of Chronic Administration of Aegle Marmelos Seed Extract on Learning and Memory in Diabetic Rats
Objective(s) Diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. Aegle marmelos Corr. from Rutaceae family is widely used in Iranian folk medicine for the treatment of diabetes mellitus. Considering the beneficial antidiabetic and antioxidant potential of A. marmelos, this study was conducted to evaluate the effect of oral administration of A. ma...
[ 2 ] - Analgesic and Anti-inflammatory Activity of Teucrium chamaedrys Leaves Aqueous Extract in Male Rats
Objective(s) Current study was undertaken to investigate the analgesic and anti-inflammatory effects of the aqueous extract of Teucrium chamaedrys in mice and rats. Materials and Methods For evaluating of analgesic and anti-inflammatory activity, we used the carrageenan- and dextran-induced paw oedema, acetic acid-induced writhing, tail flick and formalin pain tests. Results The extract of...
[ 3 ] - Effects of Boswellia Papyrifera Gum Extract on Learning and Memory in Mice and Rats
Objective(s) Learning is defined as the acquisition of information and skills, while subsequent retention of that information is called memory. The objective of the present study was to investigate the effect of aqueous extract of Boswellia papyrifera on learning and memory paradigms in mice and rats. Materials and Methods This study was held at the Department of Pharmacology, Faculty of Pha...
[ 4 ] - Antinociceptive Effect of Promethazine in Mice
Objective(s) The present study was undertaken to investigate the nociception activity of promethazine, a tranquillizer devoid of hypnotic activity in mice. Materials and Methods Antinociception was evaluated, using the acetic acid-induced writhing, tail flick, hot plate and formalin pain tests. Results Promethazine (4 and 6 mg/kg) and acetylsalicylic acid (100 mg/kg) produced a significant...
[ 5 ] - A Sensitive Liquid Chromatographic Method for the Analysis of Clarithromycin with Pre-Column Derivatization: Application to a Bioequivalence Study
Objective(s) A sensitive liquid chromatographic method for the analysis of clarithromycin- a macrolide antibiotic- in human serum, using pre-column derivatization with 9-fluorenylmethyl chloroformate (FMOC-Cl) is described. Materials and Methods The method involved liquid-liquid extraction of the drug and an internal standard (amantadine) followed by pre-column derivatization of the analytes...
[ 6 ] - Antinociceptive and antiinflammatory effects of Teucrium hyrcanicum aqueous extract in male mice and rats
Abstract Introduction: The aim of this study was to investigate the antinociceptive and antiinflammatory effects of Teucrium hyrcanicum aqueous extract in male mice and rats. Methods: To assess the antiinflammatory effect, we used carrageenan- and dextran-induced paw oedema and for determination of the antinociceptive effect, acetic acid-induced writhing, tail flick and formalin pain tests ...
[ 7 ] - Aegle marmelos Extract Can Enhance Memory in Rats
Diabetes mellitus is associated with disturbances of learning and memory and cognitive functioning. Aegle marmelos Corr. from Rutaceae family, is widely used in Iranian folk medicine for the treatment of diabetes mellitus. It decreases blood glucose level by improving glucose tolerance and also has lipid-lowering and antioxidant properties. Considering the beneficial antidiabetic...
[ 8 ] - High Performance Liquid Chromatographic Determination of Inactive Carboxylic Acid Metabolite of Clopidogrel in Human Serum: Application to a Bioequivalence Study
A sensitive and rapid method is described for determination of clopidogrel carboxylic acid (CCA), the inactive metabolite of the antiplatelet agent clopidogrel in human serum. The analytical procedure involves liquid-liquid extraction of the analyte and an internal standard (phenytoin) with ethyl acetate. A mobile phase consisting of 0.05 M phosphate buffer containing triethylamine (0.5...
[ 9 ] - High Performance Liquid Chromatography Determination of Sertraline in Human
An accurate and sensitive reversed-phase high-performance liquid chromatograph-ic method for determination of sertraline in human serum is described using 4-chloro-7-nitrobenzofurazan as pre-column derivatization agent. The drug and an internal standard (azithrimycin) were extracted from serum using a mixture of diethyl ether-chloroform and subjected to the pre-column derivatization with...
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