Ahmad Shanei
Department of Medical Physics and Medical Engineering, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
[ 1 ] - Sonodynamic Therapy Using Protoporphyrin IX Conjugated to Gold Nanoparticles: An In Vivo Study on a Colon Tumor Model
Objective(s) Sonodynamic therapy is a physical treatment which utilizes ultrasound waves with an appropriate sensitizer such as protoporphyrin IX (PpIX). The activation of sensitizer depends on cavitation, and therefore, high intensity ultrasound is an important necessity. Beside, high intensity ultrasound can induce side effects on the healthy tissues which have surrounded tumor. The particle...
[ 2 ] - Synergetic Effects of the Combination of Gold Nanoparticles and Ultrasound Wave on HeLa Cells
Introduction: One of the combination therapies for the treatment of cancer is ultrasound with other agents, which has received considerable attention in recent years. Ultrasound causes cavitation phenomenon that can produce some effects, such as; Reactive Oxygen Species (ROS), which results in damage to cancer cells. When a particle is in liquid, the cavitation threshold decrea...
[ 3 ] - Comparison of dosimetric radiotherapy of whole left- breast cancer using conventional tangential wedge-based techniques (CTT) and three intensity modulation techniques (IMRT)
Introduction: Whole breast radiotherapy after breast-conserving surgery decrease the risk of local recurrence. this study investigates the dosimetric aspects of intensity modulated radiotherapy (IMRT) compared to conventional tangential wedge-based beams techniques (CTT) of the whole breast in early stages breast cancer patients. Materials and Methods: Co...
[ 4 ] - Evaluation of the effect of dental filling material on IMRT treatment planning in patient with nasopharyngeal cancer
Introduction: Presence of dental filling material (DFM) such as amalgam in treatment patient with nasopharyngeal cancer (NPC) is common. Streaking artifact Arising from this high density material in computed tomography (scan), may lead to perturbation in dose calculation and dose delivery. Widespread performance of intensity-modulated radiotherapy (IMRT) for NPC using anterior...
[ 5 ] - Evaluation of the Bystander effect caused ultrasound waves on the MCF-7 cell line
Introduction: Non-target radiation effects are damages and effects that occur without the need for direct radiation exposure in cells. Bystander signals cause non-targeted irradiation effect that has been defined as radiation responses in which non-irradiated cells exhibit irradiated effects as a result of signals from adjacent irradiated cells. In this study, the bystander ef...
[ 6 ] - Evaluation of the effects of dental filling material artifacts on IMRT treatment planning in patient with nasopharyngeal cancer
Background: Presence of artifacts, caused by dental filling high-Z materials (DFM), on intensity-modulated radiation therapy (IMRT) treatment plan CT images may lead to uncertainty in head and neck calculated dose distributions. Hence, the purpose of this study was to investigate the effects of DFM on the IMRT calculated dose distribution and consequent radiobiological derived outcomes for naso...
[ 7 ] - Dosimetry evaluation of salivary glands in 3D conformal radiotherapy and intensity modulated radiotherapy in oral tongue cancer
Introduction: The purpose of this study was to evaluate the dosimetric and radiobiological parameters of salivary glands in treatment of patients with oral tongue cancer by 3D conventional radiotherapy (3D-CRT) and intensity modulated radiation therapy (IMRT) techniques. Materials and Methods: This study was performed on treatment planning of patients with oral tongue cancer in T2-3/N0 cancer s...
[ 8 ] - Destructive effects of therapeutic ultrasound and gold nanoparticles on a breast carcinoma tumor model in BALB/c mice
Background: Acoustic cavitation which occurs at high intensities of ultrasound waves can be fatal for tumor cells; however, it can be used to destroy cancer cells as an efficient therapeutic method. On the other hand, it is known that the existence of nanoparticles in a liquid decreases the acoustic cavitation onset threshold. Materials and Methods: In this work, the combined effects of therape...
[ 9 ] - Induction of a bystander effect after therapeutic ultrasound exposure in human melanoma: In-vitro assay
Background: The induction of bystander effect via ionizing radiation has been well proven. However, few studies have investigated the bystander effect following non-ionizing radiation, such as ultrasound waves. Here, the bystander effect after different sonication times on human melanoma cell line (A375), is evaluated by assessing cell viability and apoptosis. Materials and Methods: The cells w...
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