Zataria multiflora vaginal cream compared with Clotrimazole vaginal cream in the treatment of Candida vaginitis

To determine the effect of Zataria multiflora vaginal cream in signs & symptoms of Candida vaginits. A randomized, double-blind clinical trial was performed comparing one applicator of Zataria multiflora vaginal cream with one applicator of Clotrimazole vaginal cream at night for a week. 61 women with candida vaginitis were enrolled. 30 of 62 women treated with Zataria multiflora vaginal cream and 31 of 62 women with Clotrimazole vaginal cream. Zataria multiflora vaginal cream Significantly reduced all symptoms except vaginal irritation & burning (P0.05). No difference in efficacy of two cream was noted, according to overall assessment by the clinicians. (P=0.071). There was no significant adverse reactions in 2 groups. A 7-day regimen of Zataria multiflora given as intravaginal cream was more effective than a 7-day regimen of Clotrimazole vaginal cream for treatment of Candida vaginits.