Vitamin D3 Reduction in Individuals Exposed to Sulfur Mustard

Authors

  • Mohammad Mehdi Adibzadeh Seresgi Department of Immunology, Immunoregulation Research Center, Shahed University, Tehran, Iran.
  • Soghrat Faghihzadeh Department of Immunology, Immunoregulation Research Center, Shahed University, Tehran, Iran.
  • Susan Ardestani Kaboudanian Department of Biochemistry, Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran. 
  • Tooba Ghazanfari Department of Immunology, Immunoregulation Research Center, Shahed University, Tehran, Iran.
Abstract:

Background: Inflammatory responses in individuals exposed to sulfur mustard occur in some organs such as lung, skin and eyes. These organs manifest overreaction in cellular and humoral immune responses. Over a long period, the immune responses often continues toward chronic inflammatory processes with some interventions. Obviously some elements have been deregulated. Therefore, this study evaluated Vitamin D3 levels as a modulatory agent that could first regulate inflammatory interactions, then switch to suppress inflammatory mechanisms. Several studies showed that Vitamin D3 plays an undeniable role in suppressing inflammatory responses. In addition, some studies showed that calcium and phosphorus could play some role in inflammatory responses, too. Also, levels of serum calcium and phosphorus are associated with serum Vitamin D3 level, because it promotes absorption and reabsorption of calcium and phosphorus in intestine and kidney.Materials and Methods: Levels of vitamin D3, calcium and phosphorus were measured by ELISA and spectrophotometric method, respectively. 114 exposed individuals as case group and 79 unexposed as control group were evaluated.Results: The results showed that the level of serum Vitamin D3 is low in individuals exposed to sulfur mustard (PConclusion: According to our findings, chronic inflammation has correlation with status of serum Vitamin D3 deficiency in individuals exposed to sulfur mustard.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Methylation of IFN-γ in sulfur mustard-exposed patients

Introduction: IFN-γ is one of the most important cytokines in the development of chronic inflammatory diseases such as asthma and COPD. The IFN-γ promoter methylation at CpG islands could be altered by various chemical and toxic substances which may have a role in the incidence of chronic pulmonary diseases and its severity. Thereby, the present study was aimed to evaluate the effect of sulfur ...

full text

Serum Matrix Metalloproteinase Levels in Patients Exposed to Sulfur Mustard

BACKGROUND Matrix metalloproteinases (MMPs) are a group of endopeptidases which comprised of various types. These proteolytic enzymes are zinc-dependent and play role in degradation of extracellular matrix (ECM). Various types of cells such as macrophages, fibroblasts, neutrophils, synovial cells and some epithelial cells secrete MMPs. According to previous studies on bronchiolitis and respirat...

full text

evaluation of apoptosis in the lung tissue of sulfur mustard-exposed individuals

lung exposure to sulfur mustard (sm) results in pulmonary complications, which is the main cause of long-term disability and morbidity. up to now, the precise mechanisms of sm-induced lung complications has not been identified. the aim of this study was to evaluate apoptosis in the lung tissue of sm-exposed individuals. the study was performed on archived lung paraffin-embedded tissue specimens...

full text

IMMUNOHAEMATOLOGICAL AND CYTOGENETICAL STUDIES ON HUMAN POPULATION EXPOSED TO SULFUR MUSTARD

The patients evaluated in this study were classified into three groups of severe, moderate, and mild according to the severity of exposure to sulfur mustard. We evaluated the Immunological and Cytogenetical status of the patients after eight years of their exposure to sulfur mustard. The investigations revealed that the number of neutrophils, lymphocytes and monocytes in the patients with sever...

full text

Prostate Specific Antigen Level in Exposure to Sulfur Mustard

Background: Oxidants and inflammation agents are predisposing factors for the development of prostate cancer. As a chemical warfare, sulfur mustard (SM) can cause cancer through various pathways mainly increased production of oxidants and inflammation. Due to high incidence of cancer in SM victims, concentration of prostate specific antigen (PSA) in SM victims was evaluated and compared with th...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 1  issue 2

pages  93- 100

publication date 2018-07-01

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023