Vitamin D3 intoxication induced secondary Hypertension

Background: The effects of vitamin D in skeletal system, biological metabolism and immune system function are well shown. Cholecalciferol (vitamin D3) and ergocalciferol (vitamin D2) are two major types of vitamin D. Vitamin D deficiency is widely in human population and vitamin D intoxication is very rare. Case Description: The patient is 37-years old bodybuilder man who referred to emergency room with acute hypertension and headache without any medical history. In the laboratory examination, elevation in calcium and serum creatinine level were observed, but there were no specific signs and symptoms of renal failure. After investigation, vitamin D intoxication was confirmed and it was due to excessive intake of vitamin D supplements. Discussion and conclusion: The vitamin D3 is involved in calcium hemostasis. The effect of acute hypercalcemia on blood pressure was established.  Hypercalcemia can cause an elevation in blood pressure, and renal failure may predispose to hypertensive response. Often clinical symptoms associated to vitamin D intoxication is related to acute renal failure (ARF). Hypertension without ARF symptom can emphasis on the relationship between acute hypercalcemia and hypertension.