Usefulness of an Automatic Quantitative Method for Measuring Regional Cerebral Blood Flow Using 99mTc Ethyl Cysteinate Dimer Brain Uptake Ratio

Authors

  • Asato Ofuji Graduate School of Health Sciences, Kumamoto University, Kumamoto, Japan
  • Kosuke Yamashita Graduate School of Health Sciences, Kumamoto University, Kumamoto, Japan
  • Rieko Nagaoka Department of Radiology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukoka, Japan
  • Shigeki Ito Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
  • Shinnichi Orita Department of Radiology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukoka, Japan
  • Taeko Tomimatsu Department of Radiology, Clinical Research Institute, National Hospital Organization Kyushu Medical Center, Fukoka, Japan
  • Yoshikazu Uchiyama Department of Medical Imaging, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan
Abstract:

 Objective(s): Improved brain uptake ratio (IBUR), employing 99mTc-ethyl cysteinate dimer (99mTc-ECD), is an automatic non-invasive method for quantitatively measuring regional cerebral blood flow (rCBF). This method was developed by the reconstruction of the theory and linear regression equation, based on rCBF measurement by H215O positron emission tomography. Clarification of differences in rCBF values obtained by Patlak plot (PP) and IBUR method is important for clinical diagnosis during the transition period between these methods. Our purpose in this study was to demonstrate the relationship between rCBF values obtained by IBUR and PP methods and to evaluate the clinical applicability of IBUR method. Methods: The mean CBF (mCBF) and rCBF values in 15 patients were obtained using the IBUR method and compared with PP method values. Results: Overall, mCBF and rCBF values, obtained using these independent techniques, were found to be correlated (r=0.68). The mCBF values obtained by the IBUR method ranged from 18.9 to 44.9 ml/100g/min, whereas those obtained by the PP method ranged from 34.7 to 48.1 ml/100g/min. The rCBF values obtained by the IBUR method ranged from 16.3 to 60.2 ml/100g/min, whereas those obtained by the PP method were within the range of 26.7-58.8 ml/100g/min. Conclusion: The ranges of mCBF and rCBF values, obtained by the IBUR method, were approximately 60% lower than those obtained by the PP method; therefore, this method can be useful for diagnosing lower flow area. Re-analysis of prior PP data, using the IBUR method, could be potentially useful for the clinical follow-up of rCBF.      

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Regional cerebral blood flow and distribution of [99mTc]ethyl cysteinate dimer in nonhuman primates.

Increases in regional cerebral blood flow have been described in a variety of cerebral pathologic states, including stroke and seizure disorders. The usefulness of technetium-99m-labeled cysteinate dimer as a marker in the measurement of regional cerebral blood flow was tested in five cynomolgus monkeys. To expand the range of blood flow to beyond the normal limits, 40 mg/kg i.v. of the carboni...

full text

Regional Cerebral Blood Flow and Distribution of [Tc] Ethyl Cysteinate Dimer in Nonhuman Primates

Increases in regional cerebral blood flow have been described in a variety of cerebral pathologic states, including stroke and seizure disorders. The usefulness of technetium-99m-labeled cysteinate dimer as a marker in the measurement of regional cerebral blood flow was tested in five cynomolgus monkeys. To expand the range of blood flow to beyond the normal limits, 40 mg/kg i.v. of the carboni...

full text

Evaluation of an automatic non-invasive quantitative measurement method of the regional cerebral blood flow

full text

[Autoradiographic method for measuring regional cerebral blood flow in rat].

脳 血管 障害 に おいて脳 循環 代謝 の検 索 は病 態把握 さ らには 治療 の上 に も有 用で あ り,日 常 診療 で もひろ く 用 い られて い る.臨 床的 に はradioisotopeを 利用 した 方 法 が 用 い られ,最 近 で はSPECT(singlephoton emissionCT)やPET(positronemissiontomography)に よ り脳血 流量,脳 酸 素消 費量 な どが測 定 されて い る. 実験 的 な脳 虚 血 やhyperglycemiaな ど種 々の モ デ ルに おい て も局所 の脳 血流 量や 脳代謝 量 の絶対値 を求 め る ことは病態 生理解 明 の上で 意義 のあ る不可 欠な検 索 手段 で あ り,種 々の実 験 デ ー タと ともに利 用 され る. 動 物実 験 にお ける脳血 流量 の...

full text

Regional cerebral blood flow using quantitative MR angiography.

BACKGROUND AND PURPOSE We sought to derive regional cerebral blood flow using vessel flows from quantitative MR angiography (qMRA). MATERIALS AND METHODS Flow rates in the 15 major cerebral arteries were measured on retrospectively gated fast 2D phase-contrast MR angiography obtained in 83 healthy adult volunteers (age range, 24-74 years; mean, 42 years). The arterial network of the brain was...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 3  issue 2

pages  77- 82

publication date 2015-07-01

{@ msg @}

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023