Toll Like Receptor-4 896A/G Gene Variation, a Risk Factor for Migraine Headaches

Authors

Alireza Rafiei Molecular and Cell Biology Research Center, Sari Medical School

Behrouz Bazrafshan Neurology Ward, Department of Internal Medicine, Buali Hospital

Mahoud Abedini Neurology Ward, Department of Internal Medicine, Buali Hospital

Mohsen Tehrani Molecular and Cell Biology Research Center, Sari Medical School

Seyed Hamzeh Hosseini Psychiatry and Behavioral Research Center, Zare Hospital, Sari Medical School, Mazandaran University of Medical Sciences, Sari, Iran

Zahra HosseiniKhah Molecular and Cell Biology Research Center, Sari Medical School

Abstract:

Background: The pathogenesis of migraine involves immune-mediated mechanisms in the vascular endothelium. Toll like receptor 4 (TLR-4) is a signaling receptor of innate immunity which plays a role in various neuropathologies related to neuron inflammation. Objective: This case/control study is aimed to investigate whether TLR- 4 896A/G variation is related to migraine headaches in an Iranian population. Methods: A total of 170 migraine patients (130 females, mean age 33.24 ± 11 years) and 170 age, sex, and ethnicity matched healthy controls (118 females, mean age of 31 ± 10 years) were recruited. Genotyping was carried out using the tetra primer amplification refractory mutation system (ARMS)-PCR. Results: The frequency of G allele was higher in migraine patients than the controls (15% vs. 4.7%; p

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