The role of ATP-dependent K+ channels in antinociception, tolerance and morphine dependence

Authors

  • Abolhassan Ahmadiani Department of Pharmacology, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, I.R. Iran
  • Mohammad Javan Department of Pharmacology, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, I.R. Iran
  • Tahereh Jesmani Department of Pharmacology, School of Medicine, Shaheed Beheshti University of Medical Sciences, Tehran, I.R. Iran
Abstract:

  Tolerance and dependence are two main problems that have limited morphine administration as an analgesic drug and they might be as a result of changes in the number and affinity of receptors, dysfunction of adenylate cyclase, impaired coupling between activated µ receptor and K+ channels, and changes in the K+ and Ca2+ channels. There are several reports concerning the role of some of these factors in the occurrence of tolerance and dependence. It has been suggested that KATP channels are involved in morphine-induced analgesia. In this study the effect of a constitutive KATP opening state by chronic administration of minoxidil (a KATP opener) on morphine tolerance and dependence was studied using tail-flick test. A single dose (5 mg/kg) of morphine, but not its chronic administration produced analgesia (p<0.001). In addition single and chronic (2 mg/kg) administration of minoxidil produced analgesia (p<0.0001 vs ethanol) and chronic co-administration of morphine and minoxidil did not reduce morphine tolerance, while It reduced jumping (p<0.01) and weight loss (p<0.05) as signs of dependence. Naloxone did not antagonize minoxidil analgesia. Morphine analgesia was reduced by glibenclamide 2 mg/kg (p<0.001). These results may suggest that co-administration of morphine and minoxidil is able to reduce some dependence signs of morphine. Since this treatment reduced the jumping and weight loss, but not the writhing sign, it is concluded that different mechanisms and sites of action are involved in the development of each of the dependence signs.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

the analysis of the role of the speech acts theory in translating and dubbing hollywood films

از محوری ترین اثراتی که یک فیلم سینمایی ایجاد می کند دیالوگ هایی است که هنرپیش گان فیلم میگویند. به زعم یک فیلم ساز, یک شیوه متأثر نمودن مخاطب از اثر منظوره نیروی گفتارهای گوینده, مثل نیروی عاطفی, ترس آور, غم انگیز, هیجان انگیز و غیره, است. این مطالعه به بررسی این مسأله مبادرت کرده است که آیا نیروی فراگفتاری هنرپیش گان به مثابه ی اعمال گفتاری در پنج فیلم هالیوودی در نسخه های دوبله شده باز تولید...

15 صفحه اول

Role of Na(+), K(+)-ATPase in morphine-induced antinociception.

We evaluated the modulation by Na+,K+-ATPase inhibitors of morphine-induced antinociception in the tail-flick test and [3H]naloxone binding to forebrain membranes. The antinociception induced by morphine (1-32 mg/kg, s.c.) in mice was dose-dependently antagonized by ouabain (1-10 ng/mouse, i.c.v.), which produced a significant shift to the right of the morphine dose-response curve. The i.c.v. a...

full text

Attenuation of morphine tolerance and dependence by thymoquinone in mice

Objectives: Dependence and tolerance are major restricting factors in the clinical use of opioid analgesics. In the present study, the effects of thymoquinone, the major constituent of Nigella sativa seeds, on morphine dependence and tolerance were investigated in mice. Materials and Methods: Male adult NMRI mice were made tolerant and dependent by repeated injections of morphine (50, 50, and 7...

full text

the role of russia in transmission of energy from central asia and caucuses to european union

پس ازفروپاشی شوروی،رشد منابع نفت و گاز، آسیای میانه و قفقاز را در یک بازی ژئوپلتیکی انرژی قرار داده است. با در نظر گرفتن این منابع هیدروکربنی، این منطقه به یک میدانجنگ و رقابت تجاری برای بازی های ژئوپلتیکی قدرت های بزرگ جهانی تبدیل شده است. روسیه منطقه را به عنوان حیات خلوت خود تلقی نموده و علاقمند به حفظ حضورش می باشد تا همانند گذشته گاز طبیعی را به وسیله خط لوله مرکزی دریافت و به عنوان یک واس...

15 صفحه اول

α-Terpineol attenuates morphine-induced physical dependence and tolerance in mice: role of nitric oxide

Objective(s):Dependence and tolerance to opioid analgesics are major problems limiting their clinical application. a-Terpineol is a monoterpenoid alcohol with neuroprotective effects which is found in several medicinal plants such as Myrtus communis, Laurus nobilis, and Stachys byzantina. It has been shown that some of these medicinal plants such as S. byzantina attenuate dependence and toleran...

full text

Tolerance for ATP-insensitive K(ATP) channels in transgenic mice.

To examine the role of sarcolemmal K(ATP) channels in cardiac function, we generated transgenic mice expressing GFP-tagged Kir6.2 subunits with reduced ATP sensitivity under control of the cardiac alpha-myosin heavy chain promoter. Four founder mice were isolated, and both founders and progeny were all apparently normal and fertile. Electrocardiograms from conscious animals also appeared normal...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 3  issue None

pages  109- 114

publication date 1999-11

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023