The protective Effect of Nigella sativa on sperm parameter in mice treated with dexamethasone

Authors

  • abouzaripour, morteza Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • daneshi, Erfan Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Fathi, Fardin Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • khalesro, shiva Agronomy and plant breeding, department faculty of agriculture university of Kurdisan, Sanandaj, Iran
  • miri, saeid Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
  • nikkho, bahram Department of pathology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • Rezaie, Mohammad Jafar Department of anatomical sciences, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
  • roshani, daem Department of Epidemiology and Biostatistics , School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran
Abstract:

Background and Aim: Dexamethasone affects testis hemostasis through reduction of  testosterone level . In one study dexamethasone induced spermatogenesis defects through epithelial vacuolizations and sloughing of germ cell layer. Material and Methods: Forty NMRI mice were randomly divided into four groups. Control and dexamethasone groups received normal saline and dexamethasone (5 mg/kg) respectively for 7 days. Dexamethasone and Nigella sativa(NS) (5 mg/kg) were given to the third group and the fourth group(Nigella sativa group) received 5 mg/kg  Nigella sativa for 7 days. Epididymal sperm parameters were used for evaluation of the effects of dexamethasone and Nigella sativa on testis.   Results: Epididymal sperm parameters) count,motility and abnormal sperm) showed significant alterations in dexamethasone group (p<0.05). Treatment with NS+ dexamethasone significantly prevented these changes (p<0.05). Conclusion:Numerous studies have been performed to evaluate destructive effects of dexamethasone on  male reproductive system. The aim of this study was to assess protective effect of Nigella sativa against the side effects of dexamethasone on male reproductive system. We found that dexamethasone could decrease sperm parameters. These changes were reduced by using Nigella sativa.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The Protective Effect of Quercetin on Sperm Parameters and Serum Biochemical Factors in Adult Mice Treated with Dexamethasone

Background and Objectives: Dexamethasone is a synthetic glucocorticoid, which causes oxidative stress in the testicular tissue. This study aimed to investigate the protective effect of quercetin as a powerful antioxidant on sperm parameters and serum biochemical factors in mature adult mice following the treatment with dexamethasone.   Methods: In this experimental study, 24 mature adult male ...

full text

Protective effect of Nigella sativa on sperm parameters in mice exposed to titanium dioxide during embryonic development

Background and Aim: Nanotechnology is the precise and controlled manipulation of the atomic or molecular structure of nanoscale materials for the preparation of particulate matter with new properties and specific applications. Many in vivo and in vitro studies have shown the negative and destructive effects of nanoparticles on male germ cells.Nanoparticles include primary particles with at leas...

full text

Protective Effect of Pentoxifylline on Sperm and Biochemical Parameters against Dexamethasone-Induced Toxicity in Mice

Background and purpose: Nowadays, the side effects of chemical drugs such as dexamethasone, as a steroidal anti-inflammatory factor, is considered on reducing male reproductive potential. The aim of this study was to evaluate the effect of pentoxifylline on sperm parameters and biochemical factors in mice treated with dexamethasone. Materials and methods: In this study, 24 adult male NMRI mice...

full text

Protective Effect of Nigella Sativa Seeds on Ccl4-induced Hepatotoxicity

The role of Nigella Sativa (NS) was investigated in the prevention of carbon tetrachloride (CCl4) induced liver fibrosis. Twenty seven adult wistar-albino rats were allocated into three groups (control, CCl4-induced hepatotoxicity and hepatotoxicity and NS-treated) and after the treatment, rats were sacrified, blood samples were collected for determination of plasma aminotransferases, malondial...

full text

the washback effect of discretepoint vs. integrative tests on the retention of content in knowledge tests

در این پایان نامه تاثیر دو نوع تست جزیی نگر و کلی نگر بر به یادسپاری محتوا ارزیابی شده که نتایج نشان دهندهکارایی تستهای کلی نگر بیشتر از سایر آزمونها است

15 صفحه اول

Study of the protective effect of Nigella sativa against Cimetidine induced reproductive toxicity in male mice

The present study was designed to investigate some histopathological changes produced by cimetidine on male reproductive organs (testes & epididymis) in mice and extended to examine wherethere using of aqueous suspension of powdered Nigella sativa seeds have ability to reduce this toxicity.Forty male mice were divided into 4 groups. The first group received 25 mg/kg B.W. of cimetidine orally on...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 25  issue 3

pages  99- 105

publication date 2020-07

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023