The Interaction between Dietary Fiber and the Mediterranean Dietary Pattern Score with FTO Gene Polymorphisms in Relation to Obesity Phenotypes
Authors
Abstract:
Introduction: Although variants in the FTO gene have been found to be associated with susceptibility to obesity, however, recent studies suggest that dietary intakes may modify the association. This study aimed to investigate the interaction of the Mediterranean dietary pattern (MD) and fiber intake with FTO gene polymorphisms in relation to obesity phenotypes. Materials and Methods: Participants of this nested case-control study (n=1254) were selected among adult participants of the Tehran Lipid and Glucose Study. All (n=627, generally obese, BMI≥30 kg/m2) were individually matched with controls (n=627, normal weight). Six selected SNPs (rs1421085, rs1121980, rs17817449, rs8050136, rs9939973, and rs3751812) were genotyped. The MD score was computed and Genetic Risk Scores (GRS) were calculated using the weighted method. Results: Adherence to the MD could modify the association of three SNPs (rs17817449, rs8050136, and rs3751812) with general and abdominal obesity (Waist circumference≥95 cm) (P interaction=Pi<0.05). The odds of abdominal obesity in risk allele carriers of rs3751812 (TG+TT) decreased along with increasing dietary fiber intake (Pi=0.01), compared to subjects with no risk alleles. The risk of general obesity in participants with a high GRS decreased during the MD score quartiles, compared to those with a low GRS (Pi<0.05). The risk of developing general obesity in people with GRS≥6 was reduced by increasing fiber intakes (P trend<0.05). Conclusion: A higher adherence to the MD pattern and fiber intakes can decrease obesity risk in risk allele carriers of three FTO polymorphisms, rs17817449, rs8050136 and rs3751812.
similar resources
Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes
There is increasing interest of which dietary patterns can modify the association of fat mass and obesity associated (FTO) variants with obesity. This study was aimed at investigating the interaction of the Mediterranean dietary pattern (Med Diet) with FTO polymorphisms in relation to obesity phenotypes. Subjects of this nested case-control study were selected from the Tehran Lipid and Glucose ...
full textThe Relation between Dietary Nitrate and Nitrite Intake and Obesity Phenotypes: Tehran Lipid and Glucose Study
Background and purpose: Obesity is one of the major health problems that is highly prevalent in the world. There is controversial evidence about the association between dietary nitrate and nitrite and obesity. The aim of this study was to investigate the association between dietary nitrate and nitrite intake and incidence of obesity phenotypes. Materials and methods: A prospective approach was...
full textAssociations between Dietary Diversity Scores and Obesity Phenotypes in Women
Background and Objectives: Dietary diversity is a proxy measurement of overall dietary quality. The aim of this study was to assess relationships between dietary diversity score and obesity phenotypes in women, Tehran, Iran. Materials and Methods: In this cross-sectional study, 197 women aged ≥ 25 years from Municipal District 7 of Tehran were participated. Food intakes were calculated using s...
full textEvaluating the Relationship between Dietary Pattern and Dietary Self-Efficacy in Teenage Girl Students
Background & aim: Dietary patterns have dramatically changed in all age groups, especially the teenagers in the Iranian population. It was needed to identify the prevalence of dietary patterns and its determinants in this age group. Health behavior is one factor that influence dietary patterns and self-efficacy is a strong factor for behavior improvement. Therefore, th...
full texton the relationship between self- regulated learning strategies use and willingness to communicate in the context of writing
این تحقیق به منظور بررسی رابطه بین میزان استراتژیهای خود-تنظیم شده یادگیری و تمایل به ایجاد ارتباط دانشجویان زبان انگلیسی انجام شده است.علاوه بر این،روابط و کنش های موجود بین ریزسنجه های استراتژیهای خود-تنظیم شده یادگُیری ، مهارت نگارش و تمایل به برقراری ارتباط و همچنین تاٍثیرجنسیت دانشجویان زبان انگلیسی در استراتژیهای خود-تنظیم شده یادگیری و تمایل به برقراری ارتباط آنها مورد بررسی قرار گرفته شد.
15 صفحه اولAssociation between dietary acid load with alternative Mediterranean diet and dietary approaches to stop hypertension among Tehranian women
Background & Objective: There are few studies that have been examined the association between dietary acid load and healthy diet patterns. The purpose of this study was to evaluate the association between dietary acid load with alternative Mediterranean diet score (aMED) and dietary approaches to stop hypertension (DASH). Matrrials & Methodes: This cross-sectional study was conducted among 270 ...
full textMy Resources
Journal title
volume 21 issue 1
pages 9- 20
publication date 2019-07
By following a journal you will be notified via email when a new issue of this journal is published.
No Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023