The Effects of Eight-Week Resistance Training on Fatty Liver and Lipid Profile Indices, Insulin Resistance and Body Composition in Diabetic Women with Non-Alcoholic Fatty Liver disease

    The Effects of Eight-Week Resistance Training on Fatty Liver and Lipid Profile Indices, Insulin Resistance and Body Composition in Diabetic Women with Non-Alcoholic Fatty Liver disease   Running Title: The effect of  resistance training on fatty liver and metabolic indices   Khadijeh Fereidoonfara1, Amirabbas Monazzami 2*, Zohreh Razimi 3, Mehrali Rahimi4   1. PHD student at The Department of sport physiology, Faculty of sport science, Razi University, Kermanshah, Iran. ORCID: 0000-0003-4482-9964 2. Assistant Professor at The Department of sport physiology , Faculty of sport science, Razi University, Kermanshah, Iran. ORCID: 0000.0002-9086-0084 *(Corresponding Author):tel:09127261026,08334273272, fax:08334274585,E mail: [email protected] 3. Professor, Department of Clinical Biochemistry, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah,Iran, ORCID: 0000-00017589-3307 4. Professor, Endocrinologist, Diabetes Research Center, University of Medical Sciences and Health Services, Kermanshah,Iran, ORCID: 0000-0003-0900-5740 Address: Kermanshah, Bagh Abrisham, Razi University, Faculty Sports Sciences,.postal code:6714414971   Abstract   Background: The aim of this study was to determine the effects of eight weeks resistance training on fatty liver and lipid profile indices, insulin resistance and body composition in diabetic women with NAFLD. Methods: In this study, 30 diabetic women (age 48± 8, height 158± 2, weight 76± 8) with non-alcoholic fatty liver participated. Subjects were randomly divided into two groups of control (n = 15) and exercise (n = 15). The training group performed resistance training of upper and lower body muscles in  in each session and three sessions per week for eight weeks. The control group did not perform any exercise program. One repetition maximum (1RM) test and ELISA technique were used to measure leg and chest muscle strength, fatty liver and lipid profile indices, respectively. Two-way ANOVA test with repeated measures was used to determine the differences. with confidence interval of P < 0.05. Results: The results showed that in within group comparison HDL, ALT and AST variables were significantly different in the control group (P <0.05). Also, in the between group comparison, the results showed that there was a significant difference between the control and training groups in the variables of body composition, fat profile and fatty liver (P <0.05). Conclusions: These results suggest that resistance training can bring the levels of fat profile variables and liver enzymes closer to normal by compensating for the destructive effects of type 2 diabetes and non-alcoholic fatty liver in HDL, ALT and AST variables.