The Effect of Ginkgo on Baclofen Induced Amnesia using Passive Avoidance Learning and Memory in Rats

Background & Objective: Ginkgo biloba is an herbal medicine that has a positive effect on improving memory. It prevents oxidative damage in mitochondria and cell death in a variety of Neuropathies. Besides, baclofen is prescribed for its analgesic and anti-inflammatory effects but has negative impact on memory. The objective of this study is to investigate the interaction of ginkgo with GABA b receptor agonist (baclofen) by passive avoidance behavior in mice. Materials & Methods: Passive avoidance learning and memory method was used to evaluate memory by I maze shuttle box. The rats were divided into six groups. The first group were fed with only oral Ginkgo. The second and the third groups received different dosages of intraperitoneal baclofen. Groups four and five received both ginkgo and baclofen. The sixth group, as the control group, received only saline. All the injections were performed at a certain time in a day. Result: The injection of ginkgo alone, compared with control group, didn’t create any significant change in memory. The injection of different dosages of baclofen decreased the memory significantly . The injection of both ginkgo and baclofen improved memory . Conclusion: Administration of baclofen reduces and impairs memory. Ginkgo improved baclofen induced amnesia. It seems that this operation is done by interference with GABA neurotransmitters. Ginkgo biloba can possibly be used as an adjuvant drug to decrease the side effects of baclofen.