The Effect of Ascorbic Acid and Garlic Administration on Lead-Induced Apoptosis in Rat Offspring\'s Eye Retina
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Abstract:
Introduction: Lead toxicity induces retinal cell apoptosis. Vitamin C and garlic may decrease lead-induced apoptosis. This study was undertaken to investigate vitamin C and garlic protective effects on lead-induced apoptosis in eye retina. Methods: Pregnant Wistar rats (n = 72) were divided randomly into 9 groups: (L) treated rats with lead acetate in drinking water and (L+AA) with leaded water and vitamin C intraperitoneally(L+G), the rats received leaded-water and garlic juice via gavage (L+AA+G) treated rats with leaded water, ascorbic acid, and garlic juice, (AA) with ascorbic acid, and (G) with garlic juice (AA+G) treated rats with vitamin C and garlic juice and (Sh) with tap water plus normal hydrogen chloride (HCl) and glucose normal (N). After 21-day lactation, blood lead level (BLL) in rats was measured, and then their offspring and the rat offspring's eyes were removed and processed for using TUNEL method. TUNEL positive cells in the eye retina were counted and all groups were compared. Results: BLL increased in L group compared to the control groups and decreased significantly in L + G, L + AA, and L+ AA + G groups compared to L group (P<0.05). TUNELL positive cell number in eye retina significantly increased in L group compared to control groups (P<0.05) and decreased in L+ G, L+ AA, and L+AA + G groups compared to L group (P<0.05). Conclusion: Garlic juice and ascorbic acid administration during pregnancy and lactation may protect lead-induced apoptosis in rat offspring's eye retina.
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the effect of ascorbic acid and garlic administration on lead-induced apoptosis in rat offspring's eye retina
introduction: lead toxicity induces retinal cell apoptosis. vitamin c and garlic may decrease lead-induced apoptosis. this study was undertaken to investigate vitamin c and garlic protective effects on lead-induced apoptosis in eye retina. methods: pregnant wistar rats (n = 72) were divided randomly into 9 groups: (l) treated rats with lead acetate in drinking water and (l+aa) with leaded water...
full textThe effect of ascorbic acid and garlic administration on lead-induced apoptosis in rat offspring's eye retina.
INTRODUCTION Lead toxicity induces retinal cell apoptosis. Vitamin C and garlic may decrease lead-induced apoptosis. This study was undertaken to investigate vitamin C and garlic protective effects on lead-induced apoptosis in eye retina. METHODS Pregnant Wistar rats (n = 72) were divided randomly into 9 groups: (L) treated rats with lead acetate in drinking water and (L+AA) with leaded water...
full textThe Effect of Ascorbic Acid and Garlic Administration on Lead-Induced Neural Damage in Rat Offspring’s Hippocampus
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15 صفحه اولthe effect of ascorbic acid and garlic administration on lead-induced neural damage in rat offspring’s hippocampus
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full textThe Effect of Ascorbic Acid and Garlic Administration on Lead-Induced Neural Damage in Rat Offspring’s Hippocampus
OBJECTIVE(S) The aim of this study was to investigate ascorbic acid and garlic protective effects on lead-induced neurotoxicity during rat hippocampus development. MATERIALS AND METHODS 90 pregnant wistar rats were divided randomly into nine groups: 1- Animals received leaded water (L). 2- Rats received leaded water and ascorbic acid (L+AA). 3- Animals received leaded water and garlic juice (...
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Journal title
volume 17 issue 4
pages 206- 213
publication date 2013-10
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