T-helper Type 1 and 2 Cytokine Levels in Patients with Benign and Malignant Salivary Gland Tumors

Authors

  • Bijan Khademi Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine | Department of Otolaryngology, Khalili Hospital, Shiraz University of Medical Sciences, Shiraz, Iran
  • Marziyeh Tajvarpour Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine
  • Mohammad Reza Haghshenas Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine
  • Nasrollah Erfani Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine
  • Zahra Mojtahedi Cancer Immunology Group, Shiraz Institute for Cancer Research, School of Medicine
Abstract:

Background: Salivary gland tumors are among malignancies that have high recurrence rate. Immune responses in salivary gland tumors have not been well elucidated. T helper type 1 (Th1) and Th2 cytokines have been reported to play a role in the outcome of head and neck cancers. Objective: To evaluate the serum levels of interferon gamma (IFN- γ), as the hallmark of Th1 cytokines, and interleukin-4 (IL-4), as the hallmark of Th2 cytokines, in patients with benign and malignant salivary gland tumors in comparison with healthy controls. Methods: Fifty patients with benign and 14 patients with malignant salivary gland tumors, as well as 23 healthy individuals were recruited. Serum levels of IFN-γ and IL-4 were measured using ELISA method. Nonparametric tests were used for data analysis. Results: Serum levels of IFN-γ and IL-4 were found not to be significantly different in patients compared to the control group (0.68 ± 0.29 vs. 1.03 ± 0.57 pg/ml, p=0.58 for IFN-γ, 4.57 ± 1.57 vs. 4.41 ± 1.31 pg/ml, p=0.28 for IL-4). IFN-γ and IL-4 serum levels were also not significantly different between patients with benign and malignant salivary gland tumors (p=0.54 and p=0.86, respectively). Conclusion: The systemic levels of IL-4 and IFN-γ seem not to be associated with salivary gland tumor in our study. Investigation of other cytokines produced by Th1 and Th2 cells are warranted.

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Journal title

volume 13  issue 1

pages  9- 15

publication date 2016-03-01

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