Synthesis of Furo[2,3-d]pyrimidine-2,4(1H,3H)-diones From Alcohols Using T3P/DMSO

Authors

Ebrahim Soleimani Department of Chemistry, Razi University, Kermanshah 67149-67346, Iran.

Hossein Yazdani Department of Chemistry, Razi University, Kermanshah 67149-67346, Iran.

Jafar Mohammad Nejhad Department of Chemistry, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran

Mohammad Mehdi Khodaei Department of Chemistry, Razi University, Kermanshah 67149-67346, Iran.

Abstract:

T3P/DMSO is shown to be an effective and mild reagent for the one-pot synthesis of furo[2,3-d]pyrimidine-2,4(1H,3H)-diones from a variety of alcohols. Alcohols are oxidized in situ to aldehydes under mild conditions, which undergo a three-component reaction with N,N'-dimethylbarbituric acid and various isocyanides to afford furo[2,3-d]pyrimidine-2,4(1H,3H)-diones in good yields.

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Journal title

Organic Chemistry Research

volume 3 issue 1

pages 32- 36

publication date 2017-03-01

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Keywords

Furo[2 3-d]pyrimidine T3P/DMSO Oxidization Isocyanide

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