Synthesis of a carbon-14 analogue of N-(aryl-methyl)-3-phenyl-acryl amidine-[carboxy-14C] and its derivatives as NR2B-selective NMDA receptor antagonist

Authors

  • Gholamhossein Shirvani Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran
  • Kameh Esmailli Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran
  • Mohsen Javaheri Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran
  • Nader Saemian Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran
  • Omid Khalili Arjomandi Radioisotope section / Nuclear science Research School, Nuclear Science and Technology Research Institute, Tehran, P.O. Box: 11365-3486, Iran
Abstract:

Four amidine NR2B-selective NMDA receptor antagonists, N-( 2-methoxy benzyl) -3-phenyl-acrylamidine, N-[diduterio(2-methoxyphenyl) methyl]-3-phenyl-acrylamidine, N-benzyl-3-phenyl-acryl amidine and N-[diduterio(phenyl)methyl]-3-phenyl-acrylamidine, all fourlabeled with carbon-14 in the 1-position, have been synthesized as part of 5-step sequence fromBa14CO3.

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synthesis of a carbon-14 analogue of n-(aryl-methyl)-3-phenyl-acryl amidine-[carboxy-14c] and its derivatives as nr2b-selective nmda receptor antagonist

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volume 3  issue 3

pages  205- 209

publication date 2010-12-31

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