Synthesis, Characterization and Study of In Vitro Antimicrobial Activity of Some Substituted N'-[Arylidene]-2-(5-Phenyl-1H- Tetrazol-1-yl) Acetohydrazide

Authors

  • Popat Mohite Department of Pharmaceutical Chemistry, MES College of Pharmacy, Sonai, Ahmednagar, Maharashtra, India
  • Vaidhun Bhaskar MP Patel College of Pharmacy, Kapadwanj, Gujrat, India
Abstract:

      Reaction of 5-phenyl tetrazole with ethyl chloroacetate to form ethyl (5-phenyl-1H-tetrazol-1-yl) acetate (1). Compound 1 react with hydrazine hydrate in ethanol yield 2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide (2). The condensation of (2) with various aldehydes yield the corresponding substituted N'-[-arylidene]-2-(5-phenyl-1H-tetrazol-1-yl) acetohydrazide (3a- j). The compounds obtained were identified by spectral data and have been screened for antimicrobial activity. The most promising compounds having good antibacterial activity were 3b, 3c and 3i, and the best for antifungal activity were 3b, 3c and 3e.

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Journal title

volume 6  issue 3

pages  179- 184

publication date 2010-07-01

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