Synthesis and Determination of Chronic and Acute Thermal and Chemical Pain Activities of a New Derivative of Phencyclidine in Rats

Authors

  • Abbas Ahmadi Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
  • Farnaz Mihandoust Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
  • Leila Barghi Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
  • Mohsen Khalili Department of Physiology, School of Medicine, Shahed University, Tehran, Iran.
  • Ramin Hajikhani Department of Chemistry, Faculty of Science, Islamic Azad University, Karaj Branch, Karaj, Iran.
Abstract:

Phencyclidine (1-(1-phenylcyclohexyl) piperidine, PCP, I) and ketamine (2-O-chlorophenyl-2-methylaminocyclohexan, II) have shown analgesic effects. Some of its derivatives were synthesized and their biological properties have been studied. In this study, a new derivative of PCP, (1-[1-(3-methoxyphenyl) (tetralyl)] piperidine, PCP-OCH3-tetralyl, III) was synthesized and the acute thermal pain of this compound was determined using tail immersion test on rats and the results were compared with Ketamine and PCP. The results indicated a marked anti-nociception 2-25 min after ketamine injection, but the analgesic effect remained for 40 min following PCP-OCH3-tetralyl application in tail immersion test. However, the data obtained from formalin test showed that the chronic anti-nociception effect of ketamine was higher than PCP and PCP-OCH3-tetralyl exhibited almost similar analgesic effect.

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Journal title

volume Volume 9  issue Number 4

pages  379- 385

publication date 2010-12-18

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