Synthesis and Antidiabetic Evaluation of Benzenesulfonamide Derivatives

Authors

  • Abbas Shafiee Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran14176, Iran.
  • Alireza Foroumadi Drug Design and development Research Center, Tehran University of Medical Sciences, Tehran, Iran.
  • Mehdi Khoshneviszadeh Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran14176, Iran.
  • Mohamad Ebrahim Bakhshi-Dezffoli Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran14176, Iran.
  • Mohammad Abdollahi Department of Toxicology and Pharmacology, Faculty of Pharmacy and Laboratory of Toxicology, Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Tehran 14155-6451, Iran.
  • Mohammad Hasani School of chemistry, College of Science, University of Tehran, Tehran Iran.
  • Nouraddin Hosseinzadeh Department of Medicinal Chemistry, Faculty of Pharmacy and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran14176, Iran.
  • Saeed Fallah-Bonekohal Department of Toxicology and Pharmacology, Faculty of Pharmacy and Laboratory of Toxicology, Pharmaceutical Sciences Research Centre, Tehran University of Medical Sciences, Tehran 14155-6451, Iran.
Abstract:

The complex metabolic syndrome, diabetes mellitus, is a major human health concern in the world and is estimated to affect 300 million people by the year 2025. Several drugs such as sulfonylureas and biguanides are presently available to reduce hyperglycemia in diabetes mellitus. These drugs have side effects and thus searching for a new class of compounds is essential to overcome this problems. A series of seven novel N-(4-phenylthiazol-2-yl)benzenesulfonamides derivatives were synthesized and assayed in-vivo to investigate their antidiabetic activities by streptozotocin-induced model in rat. These derivatives showed considerable biological efficacy when compared to glibenclamide, a potent and well-known antidiabetic agent, as a reference drug. Four of the compounds were effective, amongst which 13 show more prominent activity at 100 mg/Kg p.o. The experimental results are statistically significant at p < 0.05 level.

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Journal title

volume 12  issue 2

pages  325- 330

publication date 2013-06-08

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