Synthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model

Authors

  • F Hadizadeh
  • H Hosseinzadeh
  • M Seifi
  • SH Kazemi
  • VS Motamed-Shariaty
Abstract:

Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test in mice. Analogues 7a-c were found to be more potent than moclobemide. Minimum effective doses for moclobemide and analogues 7a-c were found to be 20, 2.5, 1.25 and 2.5 mg/kg i.p. respectively.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

synthesis and antidepressant activity of n-substituted imidazole-5-carboxamides in forced swimming test model

moclobemide is a selective and reversible monoamine oxidase-a inhibitor, which is used as an antidepressant. three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. so, n-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1h-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...

full text

Evaluation of antidepressant effect of ethanolic extract of Rosa damascena using forced swimming test

Objective: Rosa damascena mill L (R. damascena) is a medicinal plant mostly known in the world for its perfume. It also has beneficial effects on stress, tension and depression. In this experiment antidepressant effect of ethanolic extract of R. damascena by forced swimming test (FST) was evaluated. Material and Methods: Animals received ethanolic extract (15, 60 and 90 mg/kg, i.p), imipramine...

full text

Substituted N-Phenylpyrazine-2-carboxamides: synthesis and antimycobacterial evaluation.

The condensation of chlorides of substituted pyrazinecarboxylic acids with ringsubstituted anilines yielded twelve substituted pyrazinecarboxylic acid amides. The synthetic approach, analytical, and lipophilicity data of the newly synthesized compounds are presented. Two antituberculosis assays were used. Firstly, the antimycobacterial activity against four different Mycobacterium strains in a ...

full text

Substituted N-benzylpyrazine-2-carboxamides: synthesis and biological evaluation.

A series of twelve amides was synthesized via aminolysis of substituted pyrazinecarboxylic acid chlorides with substituted benzylamines. Compounds were characterized with analytical data and assayed in vitro for their antimycobacterial, antifungal, antibacterial and photosynthesis-inhibiting activity. 5-tert-Butyl-6-chloro-N-(4-methoxybenzyl)pyrazine-2-carboxamide (12) has shown the highest ant...

full text

Omega-3 fatty acids have antidepressant activity in forced swimming test in Wistar rats.

Forced swimming test is used to induce a characteristic behavior of immobility in rats, which resembles depression in humans to some extent. We evaluated the effect of omega-3 fatty acids alone as well as compared it with the standard antidepressant therapy with fluoxetine in both acute and chronic studies. In both the studies, rats were divided into 4 groups and subjected to the following drug...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume Volume 7  issue Number 1

pages  29- 33

publication date 2010-11-20

By following a journal you will be notified via email when a new issue of this journal is published.

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023