Supplemental and Maternal Therapies

- Insights in to infertility and modern therapies -

In general, infertility is defined as the inability of couples to conceive after one year of unprotected sex. Causes of infertility can be related to both men and women. Unexplained infertility refers to the absence of a definable cause for a couplechr(chr('39')39chr('39'))s failure to achieve pregnancy, even after standard diagnostic methods including semen analysis, endometrial biopsy, etc. H...

Maternal folate status during extended lactation and the effect of supplemental folic acid.

BACKGROUND Folate requirements during lactation are not well established. OBJECTIVE We assessed the effects of dietary and supplemental folate intakes during extended lactation. DESIGN Lactating women (n = 42) were enrolled in a double-blind, randomized, longitudinal supplementation trial and received either 0 or 1 mg folic acid/d. At 3 and 6 mo postpartum, maternal folate status was assess...

Maternal intake of supplemental iron and risk of autism spectrum disorder.

Iron deficiency affects 40%-50% of pregnancies. Iron is critical for early neurodevelopmental processes that are dysregulated in autism spectrum disorder (ASD). We examined maternal iron intake in relation to ASD risk in California-born children enrolled in a population-based case-control study (the Childhood Autism Risks from Genetics and the Environment (CHARGE) Study) from 2003 to 2009 with ...

Maternal and congenital toxoplasmosis, currently available and novel therapies in horizon

Over one billion people worldwide are predicted to harbor Toxoplasma infection frequently with unknown lifelong health consequences. Toxoplasmosis is an important cause of foodborne, inflammatory illnesses, as well as congenital abnormalities. Ubiquitous Toxoplasma has a unique tropism for central nervous system with a mind-bugging effect and is transmitted sexually through semen. Currently ava...

Access and Rational use of Plasma Protein Therapies (PPTs)

Supplemental Text and Figures

ARF-BP1 enhances p42 ubiquitination To explore whether ARF-BP1 mediates p42 ubiquitination, we cotransfected GST-p42 and HAubiquitin into HEK293 cells in the presence of ARF-BP1 or MDM2, followed by MG132 treatment. ARF-BP1 strongly stimulated p42 polyubiquitination, whereas MDM2 barely influenced its ubiquitination. MG132 treatment further elevated the ubiquitination effect (Supplemental Figur...