Simple and Efficient Method for the Preparation of 5-Bromoisatins
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Abstract:
Isatin, N-methyl isatin and N-benzylisatin were smoothly monobrominated in the 5-position by treatment with pyridinium bromochromate (PBC) in acetic acid medium. In the similar conditions indigo underwent bromination and oxidation to give 5-bromoisatin in high yield.
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simple and efficient method for the preparation of 5-bromoisatins
isatin, n-methyl isatin and n-benzylisatin were smoothly monobrominated in the 5-position by treatment with pyridinium bromochromate (pbc) in acetic acid medium. in the similar conditions indigo underwent bromination and oxidation to give 5-bromoisatin in high yield.
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Journal title
volume 1 issue 1
pages 67- 71
publication date 2012-12-01
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