Sensory-Neural Hearing Loss as an Early Rebound Relapse after Fingolimod Cessation in Multiple Sclerosis
Authors
Abstract:
Introduction: Multiple sclerosis (MS) is a lifelong disease of the brain and spinal cord. Fingolimod is an oral drug which modulates the S1P receptor and is used for relapsing remitting form of MS and can causes rebound activity if it is ceased even in a short period of washout time. Case Report: Here, we introduce a young girl, a known case of MS, who developed reversible isolated unilateral sensory-neural hearing loss along imaging activity two weeks after stopping fingolimod. The patient responded well to the intravenous corticosteroid therapy which is the first line treatment of new MS attack. Conclusion: fingolimod cessation can cause rebound activity in a short period of the time. It is important to consider any new neurological sign and symptom as a rebound activity during washout time. Although SNHL is not common in MS, it could be presented as an unusual manifestation of rebound relapse after stopping fingolimod.
similar resources
Sensory neural hearing loss following Tympanomastoid surgery
Objective: Generated acoustic trauma by suction and drill may cause sensorineural hearing loss after Tympanomastoid surgery. This study was carried out to determine the relationship of sensorineural hearing loss and chronic otitis media surgery at Ahvaz Jundishapur University of Medical Sciences in Iran. Material and Methods: This prospective study included 386 patients of ch...
full textImmune Rebound: Multiple Sclerosis after Treatment of Cushing’s disease
High cortisol level in endogenous Cushing’s syndrome suppresses the immune system and after treatment there may be an over activity of immune reaction leading to autoimmune diseases mostly thyroid and rheumatologic disorders. This is the second reported case of multiple sclerosis developing after treatment of Cushing’s syndrome. A 42-year old man is reported who presented with bone fracture and...
full textsensory neural hearing loss following tympanomastoid surgery
objective: generated acoustic trauma by suction and drill may cause sensorineural hearing loss after tympanomastoid surgery. this study was carried out to determine the relationship of sensorineural hearing loss and chronic otitis media surgery at ahvaz jundishapur university of medical sciences in iran. material and methods: this prospective study included 386 patients of chronic middle ear di...
full textFingolimod and multiple sclerosis
Neurology 2012;79:1942–1943 Unexpected consequences arise from our incomplete knowledge of the immune system. Who, for example, would have predicted that natalizumab, a monoclonal antibody targeting 4 integrin on leukocytes, would dramatically increase the risk of developing progressive multifocal leukoencephalopathy without causing notable immunosuppression? Thus, any new immunomodulatory ther...
full text[Cystoid macular oedema after fingolimod treatment in multiple sclerosis].
CASE REPORT A woman, treated with immunomodulatory and immunosuppressive drugs for multiple sclerosis, developed macular oedema 4 months after oral fingolimod administration. The patient was previously seen by an ophthalmologist, with a normal anterior segment and funduscopic examination. Four months after the treatment she referred to decreased visual acuity in both eyes. The funduscopic and O...
full textFingolimod treatment in multiple sclerosis
Objective: To determine whether fingolimod, an oral sphingosine-1-phosphate receptor modulator approved for treatment of multiple sclerosis (MS), generally leads to increased retinal tissue volume. Methods: In this longitudinal observational study, we compared changes in macular volume on spectral-domain optical coherence tomography (OCT) between consecutive patients with MS who initiated fingo...
full textMy Resources
Journal title
volume 32 issue 4
pages 249- 253
publication date 2020-07-01
By following a journal you will be notified via email when a new issue of this journal is published.
Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023