Safranal-loaded solid lipid nanoparticles: evaluation of sunscreen and moisturizing potential for topical applications

safranal-loaded solid lipid nanoparticles: evaluation of sunscreen and moisturizing potential for topical applications

objective(s): in the current study, sunscreen and moisturizing properties of solid lipid nanoparticle (sln)-safranal formulations were evaluated. materials and methods:series of sln were prepared using glyceryl monostearate, tween 80 and different amounts of safranal by high shear homogenization, and ultrasound and high-pressure homogenization (hph) methods. sln formulations were characterized ...

Resveratrol-loaded solid lipid nanoparticles versus nanostructured lipid carriers: evaluation of antioxidant potential for dermal applications

BACKGROUND Excessive generation of radical oxygen species (ROS) is a contributor to skin pathologies. Resveratrol (RSV) is a potent antioxidant. Solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) can ensure close contact and increase the amount of drug absorbed into the skin. In this study, RSV was loaded into SLN and NLC for dermal applications. METHODS Nanoparticles wer...

Preparation, characterization and evaluation of moisturizing and UV protecting effects of topical solid lipid nanoparticles

Solid lipid nanoparticles (SLN) were recently proposed as carriers for various pharmaceutical and cosmetic actives. These lipid nanoparticles can act as moisturizers and physical sunscreens on their own. Therefore, the full potential of these carriers has yet to be determined. The present study was aimed to determine and compare moisturizing and UV-protecting effects of different solid lipid na...

preparation and stability evaluation of urea-loaded solid lipid nanoparticles for topical application.

Zaltoprofen Loaded Solid Lipid Nanoparticles for Topical Delivery: Formulation Design, In Vitro and Ex Vivo Evaluation

The number of new pharmaceutical compounds with poor aqueous solubility has grown steadily over the last two decades due to the progress in discovery technologies, e.g. high throughput and combinatorial screening tools, during lead development and optimization phase. Most of these compounds are mainly categorized as bio pharmaceutics classification system (BCS) class II for which their oral abs...