Rickets Due To Prolonged Use of Antiepileptic Drugs

Authors

  • Batool Behfrooz
  • George Azma
  • Khalil Zareiyan
  • Manoochehr Saboori Deylami
  • Mohammad Hossein Marandian
Abstract:

La therapeutique ant epileptique de longue duree provoque une profonde modification du metabolisme de la vitamine B et notamment une acceleration du catabolisme de celle-ci.  Les auteurs rapportent un cas de ce type particulier d'osteomalacie et la revue de la lit­terature leur permet de souligner trois points essentiels:  1 ) les besoins journaliers de la vitamine B sontaccrus chez les enfants soumis aux drogues anti-convulsives,  4- Proc.Roy. Soc. Med. 65: 730, 1972. 5- Hahn T.J. Hendin B.A. Scharp, G.R. haddad J.G. effect of chronic anticonvul­sant therapy on serum 25-Hydroxycalciferol level in adult. the New England Journal cf Medicine. 287, S00-803, 1972. 6- LIFSHITZ. F, and MacLaron, N.K: Vitamin ( D) dependent rickets in institutionalized, mentally retarded children receiving long - term anticonvulsant therapy. Journal of - pediatrics. 83, 612-620, 1973. 7- SILVER. J. Davies. T.J. Kupersmitt, E. Orme. M Petrie, A: Vajda, F. Prevalence and treatment of vitamin - D-deficiency in children on anticonvulsant drugs. Archives of Disease in childhood. 49: 344-49, 1974. 8- Leaidas, J.C. et, al, Chemically induced anticonvulsant therapy. Journal of children, Radiology. 109: 409-12, 1973. 9- Klipstein, R.A.: Subnormal serum folate antiepileotic therapy ;ind ricket in vulsant drug therapy, Blood 23: 68, 1964. 10- Krus, R,: Osteopathien bei antiepileptischer langzeitherapie ( Fcrlaiifige Mittellung), Monatsch, Kinderheilkd, ll6: 378, 1968. 11- Lap,lane. R. Les Spasmes eu Flexions, Rev. Prat 26: 3639, 1966. 12- Rheumatism gardenalique Camus, J.P. et, al. Rev. Prat 22,: 1963, 1972. 13- Paupe, J. Etiologie et Physiopathologie du rachitisme commun Rev. Prat 27: 8, 1967. 14--- Paupe, J. et al, Le rachitisme carentiel tardif, sen. Hop. Paris: 44: 859, 1969. 

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Journal title

volume 5  issue 2

pages  95- 104

publication date 1977-03

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