Response surface methodology for optimization of supercritical fluid extraction of orange peel essential oil

Authors

  • Ali Davoodi Department of Pharmacognosy and Biotechnology, Faculty of Pharmacy, Mazandaran University of Medical Sciences, Sari, Iran
  • Farhad Raofie Department of Chemistry, Faculty of Science, Shahid Beheshti University, G. C., Tehran, Iran
  • Kiana Ghadiri Active Pharmaceutical Research Center (APIRC), Pharmaceutical Science Branch, Islamic Azad University (IAUPS), Tehran, Iran
  • Mahnaz Qomi Active Pharmaceutical Research Center (APIRC), Pharmaceutical Science Branch, Islamic Azad University (IAUPS), Tehran, Iran
Abstract:

Background: Orange peel essential oils were obtained using supercritical fluid extraction. This method is an important high scaling extraction methods that used for extraction of plant and animal extracts. Methodology: The experimental parameters of SFE such as temperature, pressure, and extraction time and modifier volume were optimized using a central composite design after a 24-1fractional factorial design. Orange peels were collected from ripe orange and were washed, air dried and milled. Then, A Suprex MPS/225 system in the SFE mode with a maximal operating pressure of 395 bars was used for essential oil extraction. Moreover, GC-MS and GC-FID have been used for identification and determination of oil compounds, respectively. Results: Eight compounds have been identifiedbased on their retention indices and mass spectra. According to the results, α-pinene, β-pinene, myrecene, d-limonene, terpinolene, C8-aldehyde, citronellol and linalool were identified in orange peel essential oil. The optimum SFE conditions were obtained at a pressure of 347.07 atm, temperature of 55 ◦C, extraction time of 30.16 min, and ethanol volume of 147.05 µL. Moreover, extraction yields based on SFE varied in the range of 0.04% to 1.18% (w/w). Conclusion: The Results showed supercritical fluid technology as the best alternative technique for the extraction of pure and high quality essential oil from orange peel. It is a green method and does not have any environmental impact.

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Journal title

volume 6  issue 4

pages  0- 0

publication date 2020-09

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