Response of Epulis Fissuratum to nystatin therapy:Case report & Review Articles

Abstract Background and Aim: Epulis Fissuratum (EF) is a hyperplasia of mucosal fibrosis and its main cause is the use of improper prosthesis. Treatment of these lesions is necessary because any change in the natural tissue of the oral mucosa causes the accumulation of opportunistic microflora, such as Candida albicans. Therefore, this study aimed to report an interesting observation about the EF response to drug therapy. Case Report: A 62-year-old female patient referred to the Dental Clinic of Semnan University of Medical Sciences (SUMS) while suffering from a long-term mouth ulcer.Diagnosis of EF was suggested based on the clinical appearance as well as the association of the prosthesis with the lesion. Therefore, gargling a suspension of 100,000 units of nystatin four times a day was also prescribed, and oral hygiene by removing the prosthesis was recommended, in unnecessary times and at night.Subsequently, in follow-up sessions, a gradual improvement was observed unitl the disease was completely eliminated . Conclusion: It seems,  Regarding the relationship between EF and the accumulation of microorganisms, a cours of drug treatment might be notable effect on reduction size of EF.