Reinforcement learning based feedback control of tumor growth by limiting maximum chemo-drug dose using fuzzy logic

Authors

Abstract:

In this paper, a model-free reinforcement learning-based controller is designed to extract a treatment protocol because the design of a model-based controller is complex due to the highly nonlinear dynamics of cancer. The Q-learning algorithm is used to develop an optimal controller for cancer chemotherapy drug dosing. In the Q-learning algorithm, each entry of the Q-table is updated using data from states, action, and reward. The action is the chemo-drug dose. The proposed controller is implemented on a four states mathematical model including immune cells, tumor cells, healthy cells, and chemo-drug concentration in the bloodstream. Three different treatment strategies are proposed for three young, old, and pregnant patients considering his/her age. Chemotherapy is used in all cases.  In the older patient, immunotherapy is also used for modifying the dynamics of cancer by reinforcing his/her weak immune system. A Mamdani fuzzy inference system is designed to limit the maximum chemo-drug dose by regarding the age of the patients. Simulation results show the effectiveness of the proposed treatment strategy. It is also shown that immunotherapy is necessary for finite duration cancer treatment in patients with a weak immune system. The used strategy is a model-free method which is the main advantage of this method. 

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

An Adaptive Learning Game for Autistic Children using Reinforcement Learning and Fuzzy Logic

This paper, presents an adapted serious game for rating social ability in children with autism spectrum disorder (ASD). The required measurements are obtained by challenges of the proposed serious game. The proposed serious game uses reinforcement learning concepts for being adaptive. It is based on fuzzy logic to evaluate the social ability level of the children with ASD. The game adapts itsel...

full text

Reinforcement Learning Based PID Control of Wind Energy Conversion Systems

In this paper an adaptive PID controller for Wind Energy Conversion Systems (WECS) has been developed. Theadaptation technique applied to this controller is based on Reinforcement Learning (RL) theory. Nonlinearcharacteristics of wind variations as plant input, wind turbine structure and generator operational behaviordemand for high quality adaptive controller to ensure both robust stability an...

full text

RRLUFF: Ranking function based on Reinforcement Learning using User Feedback and Web Document Features

Principal aim of a search engine is to provide the sorted results according to user’s requirements. To achieve this aim, it employs ranking methods to rank the web documents based on their significance and relevance to user query. The novelty of this paper is to provide user feedback-based ranking algorithm using reinforcement learning. The proposed algorithm is called RRLUFF, in which the rank...

full text

Using fuzzy logic for performance evaluation in reinforcement learning

Current reinforcement learning algorithms require long training periods which generally limit their applicability to small size problems. A new architecture is described which uses fuzzy rules to initialize its two neural networks: a neural network for performance evaluation and another for action selection. This architecture is applied to control of dynamic systems and it is demonstrated that ...

full text

Maximum power point tracking using a fuzzy logic control scheme

This paper proposes an intelligent control method for the maximum power point tracking (MPPT) of a photovoltaic system under variable temperature and insolation conditions. This method uses a fuzzy logic controller applied to a DC-DC converter device. The different steps of the design of this controller are presented together with its simulation. Results of this simulation are compared to those...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 15  issue None

pages  13- 23

publication date 2022-01

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

No Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023