Rapid desensitization for hypersensitivity reactions to chemotherapeutic drugs; a case series

Authors

  • Bahram Bashardost Department of Immunology and Allergy, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Delara Babaie Department of Immunology and Allergy, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Hamidreza Goudarzipour Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mahdieh Vahedi Department of Pediatrics, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Masoomeh Ebrahimi Department of Pediatrics, Loghman-e- Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mehrdad Amirmoini Department of Immunology and Allergy, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Mehrnaz Mesdaghi Department of Immunology and Allergy, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
  • Nader Momtazmanesh Department of Pediatric Hematology and Oncology, Loghman-e- Hakim Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Reza Ghaemi Department of Immunology and Allergy, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  • Shahin Shamsian Pediatric Congenital Hematologic Disorders Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract:

Usage of cancer chemotherapeutics drugs can be associated with adverse drug reactions. When IgE-mediated drug reactions are formed following administration of a chemotherapeutic drug that is a drug of choice, drug desensitization protocols can be helpful. Hypersensitivity reactions can be allergic or nonallergic, but the clinical manifestations are similar. Rapid drug desensitization (RDD) is effective when used appropriately, however it is often over utilized instead of performing a drug challenge. RDD is both an acceptable approach and a high-risk treatment modality in patients in whom the first line chemotherapy is the offending agent. The sa

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Journal title

volume 18  issue 2

pages  1047- 1051

publication date 2019-05-01

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