Radiolabeling and Biodistribution of new dual modality nanoparticle probe in Nuclear Medicine

Introduction: Dual-modality contrast agents, such as radiolabeled nanoparticles, are promising candidates for a number of diagnostic applications, namely SPECT imaging with MR imaging. So the aim of study was evaluating potential of Chitosan-Coated Magnetic Nanoparticles(SPION) labeled with 99mTc as new Dual-modality probes for liver Imaging. Materials and Methods: In this study chitosan particles were coated on SPION and radiolabeled with 99mTc after Purification. The quality control tests including determining particles size, labeling efficiency, stability and Biodistribution study in the mice were performed. Finally MRI and nuclear medicine imaging study in Balb/c mice in 1 and 4 hour after injection of complex were performed. Results: Results showed that the final complex have spherical shape and with average size 255±30nm. The labeling efficiency and stability of complex with 99mTc were 89±6%, 93±6% respectively. Biodistribution study, MRI and nuclear medicine imaging showed high accumulation of Complex in liver. Conclusion: The results showed that the 99mTc-Chitosan coated SPION may be considered as promising Dual-modality probes for liver Imaging.