Radiation induced myocardial perfusion abnormalities in patients with left breast cancer: A prospective study with short and long term follow up
Authors
Abstract:
Introduction:The external beam radiation therapy for patients with left breast cancer at the mastectomy site may cause myocardial perfusion abnormalities. We intended to study the change of these abnormalities at short and long term post radiotherapy follow up. Methods: Twenty patients with left and 20 patients with right breast cancer comprised the exposed and control groups, respectively. The patients had low risk for coronary disease. They underwent myocardial perfusion scans (MPS) 3 years after the external beam radiation therapy at the bed of modified radical mastectomy. These subjects were recruited from two bigger cohorts with previously reported data of scans at 6 months. The scans were acquired after injections of about 20 mCi MIBI at peak pharmacologic stress and at rest. The change of the perfusion abnormalities by both visual assessment and quantifications (Autoquant) at the baseline and 3 years follow up time are compared between exposed and control patients. Results: The exposed patients had more visual perfusion abnormality scores compared to control subjects (1.1±1.3 vs. 0.3±1.0; p=0.03). The indices of perfusion abnormality normalized in control subjects from baseline to follow up scans (p= 0.05 for summed difference score and p=0.04 for summed stress score). The difference of the perfusion abnormalities between the exposed and unexposed subjects remained unchanged along the 3 years of follow up. Conclusion: The radiation induced myocardial perfusion abnormalities in patients with left breast cancer could cause permanent coronary disease over time.
similar resources
radiation induced myocardial perfusion abnormalities in patients with left breast cancer: a prospective study with short and long term follow up
introduction:the external beam radiation therapy for patients with left breast cancer at the mastectomy site may cause myocardial perfusion abnormalities. we intended to study the change of these abnormalities at short and long term post radiotherapy follow up. methods: twenty patients with left and 20 patients with right breast cancer comprised the exposed and control groups, respectively. the...
full textRadiation-induced myocardial perfusion abnormalities in breast cancer patients following external beam radiation therapy
Objective(s): Radiation therapy for breast cancer can induce myocardial capillary injury and increase cardiovascular morbidity and mortality. A prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of left-sided breast cancer patients as compared to those with right–sided cancer. Methods: To minimize potential confounding fact...
full textradiation-induced myocardial perfusion abnormalities in breast cancer patients following external beam radiation therapy
objective(s): radiation therapy for breast cancer can induce myocardial capillary injury and increase cardiovascular morbidity and mortality. a prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of left-sided breast cancer patients as compared to those with right–sided cancer. methods: to minimize potential confounding fact...
full textIncrease in antimullerian hormone in long-term follow-up of patients with endometrioma after laparoscopic surgery
Abstract Background: Endometriosis is a common disease which is characterized by the development of the endometrial tissue outside the uterus. The most common location of endometriosis is the ovary, occurring in 17-44% of affected patients . It is a chronic disease mostly affecting women at reproductive age. Therefore, it is important to predict and protect the patients’ ovarian function. The...
full textRadiation-induced myocardial perfusion abnormalities in breast cancer patients following external beam radiation therapy
OBJECTIVES Radiation therapy for breast cancer can induce myocardial capillary injury and increase cardiovascular morbidity and mortality. A prospective cohort was conducted to study the prevalence of myocardial perfusion abnormalities following radiation therapy of left-sided breast cancer patients as compared to those with right-sided cancer. METHODS To minimize potential confounding factor...
full textLong-term Follow-up Study of Pulmonary Function Test in Children with History of Hydrocarbon Aspiration
Background Aspiration of hydrocarbons causes several acute and chronic pulmonary complications; it may even lead to death. The aim of this study was to investigate the types of long-term pulmonary complications in children with a history of hydrocarbon aspiration. Materials and Methods In this case-control study, 21 children ...
full textMy Resources
Journal title
volume 25 issue Supplement 1
pages 21- 25
publication date 2017-02-01
By following a journal you will be notified via email when a new issue of this journal is published.
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023