Quantitative determination of three angiotensin-II-receptor antagonists in presence of Hydrochlorothiazide by RP-HPLC in their tablets preparations
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Abstract:
Losartan potassium, Valsartan , Telmisartan and Irbesartan are angiotensin-II-receptor antagonists (ARA II) group which used in treatment of hypertension alone or in combination with other drugs mainly Hydrochlorothiazide. RP- HPLC method was developed for the assay of three angiotensin-II-receptor antagonists (ARA-IIs) in presence of Hydrochlorothiazide. The method was performed by reversed phase high performance liquid chromatography using a mobile phase which is consisted of 0.025 M potassium dihydrogen phosphate (pH 6.0): acetonitrile =65:35% with detection at 220 nm on an ACE C18 column (250 mm × 4.6 mm, 5 μm) at flow rate 1.5 ml/min in an isocratic manner. The proposed method was validated according to ICH guidline in terms of linearity, accuracy, precision , robustness, limit of detection and limit of quantitation.
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quantitative determination of three angiotensin-ii-receptor antagonists in presence of hydrochlorothiazide by rp-hplc in their tablets preparations
losartan potassium, valsartan , telmisartan and irbesartan are angiotensin-ii-receptor antagonists (ara ii) group which used in treatment of hypertension alone or in combination with other drugs mainly hydrochlorothiazide. rp- hplc method was developed for the assay of three angiotensin-ii-receptor antagonists (ara-iis) in presence of hydrochlorothiazide. the method was performed by reversed ph...
full textQuantitative Determination of three Angiotensin-II-receptor Antagonists in Presence of Hydrochlorothiazide by RP-HPLC in their Tablet Preparations
Losartan potassium, Valsartan , Telmisartan and Irbesartan are angiotensin-II-receptor antagonists (ARA II) group which used in treatment of hypertension alone or in combination with other drugs mainly Hydrochlorothiazide. RP- HPLC method was developed for the assay of three angiotensin-II-receptor antagonists (ARA-IIs) in presence of Hydrochlorothiazide. The method was performed by reversed ph...
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Journal title
volume 12 issue 4
pages 635- 643
publication date 2013-11-01
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