Prophylactic Effect of Chloroquine and Hydroxy chloroquine in COVID-19 Treatment

Authors

  • Amin Ataie Department of Toxicology and Pharmacology, Babol University of Medical Science, Babol, Iran
  • Fatemeh Alibabaei Department of Toxicology and Pharmacology, Babol University of Medical Science, Babol, Iran
  • Ramin Ataee Pharmaceutical sciences research center, Hemoglobinopathy institute, Mazandaran University of medical sciences, Sari Iran
  • Razieh Mansouri Department of Toxicology and Pharmacology, Babol University of Medical Science, Babol, Iran
Abstract:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly transmissible and pathogenic coronavirus that emerged in late 2019 and has caused a pandemic of acute respiratory disease, named ‘coronavirus disease 2019’ (COVID-19), which threatens human health and public safety.Hydroxychloroquine (HCQ) is an anti-malaria drug; its antiviral properties are controversial,and some in vitro studies approved its antiviral effects. Many efforts have been made to prevent and treat coronavirus COVID-19 disease, but effective drugs for complete eradication of COVID-19 have not been found yet, and all of them are supportive. We try to review some new aspects of HCQ efficacy in the prevention and treatment of COVID-19 infection. Also, some data from recent clinical trials were studied. It has been shown that HCQ may improve some symptoms of patients, but in severe or critical stages did not have significant therapeutic effects and not reduce the rate of mortality .In the present review article, we explained some results of recent researches, including clinical trials about the effects of HCQ in the prevention and treatment of COVID-19infection.Some studies revealed HCQ beneficial effects in outpatients, and some data showed its hazardous impacts on the heart. The available evidence suggests that CQ or HCQ does not improve clinical outcomes in COVID-19. Well-designed randomized trials are required for assessing the efficacy and safety of HCQ and CQ for COVID- It was suggested that the dose of HCQ administration must be adjusted and monitored correctly; furthermore, the levels of some myocardial biomarkers such as troponin must be measured in mild to  moderate, severe, and critical infection. Also combination therapy with  other  drugs such as azithromycin may have better  anti-inflammatory and antiviral effects . Keywords: Hydroxychloroquine, COVID-19, OT-interval, Azithromycin, Replication.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

The Effect of Otostegia persica in Combination with Chloroquine on Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium berghei Using In-vivo Fixed Ratios Method

   Malaria is one of the worldwide parasitic diseases which threaten the life of hundreds of millions of people at the malarious areas each year. The emergence of chloroquine-resistant strains of Plasmodium falciparum in most of the malarious areas has encountered the relevant countries with some difficulties about treating the acute cases of the disease particulary if the monotherapy regimen h...

full text

The Effect of Otostegia persica in Combination with Chloroquine on Chloroquine-Sensitive and Chloroquine-Resistant Strains of Plasmodium berghei Using In-vivo Fixed Ratios Method

   Malaria is one of the worldwide parasitic diseases which threaten the life of hundreds of millions of people at the malarious areas each year. The emergence of chloroquine-resistant strains of Plasmodium falciparum in most of the malarious areas has encountered the relevant countries with some difficulties about treating the acute cases of the disease particulary if the monotherapy regimen h...

full text

Combination cyclosporine and (hydroxy)chloroquine in rheumatoid arthritis.

Antimalarials are attractive candidates for combination therapy. In vitro experiments have revealed a synergistic mode of action of cyclosporine and chloroquine which could not, however, be confirmed in a clinical trial.

full text

variation of the chloroquine resistance transporter (crt) gene in chloroquine-resistant and chloroquine-sensitive plasmodium berghei

background: the emergence and spread of chloroquine resistant plasmodium falciparum in the world stimulated some investigators to consider different aspects of chloroquine resistance in human and rodent plasmodia . using animal plasmo­dia , particularly primate and rodent plasmodia can be useful model for human plasmodia studies. in this study we have tried to consider and compare the sequence ...

full text

The effect of chloroquine treatment in malignant astrocytomas on prognosis

Turgay BULUT, Mehmet Ali EKİCİ*, Bülent TUCER, Seyit Kaan BAŞARSLAN, Kağan KAMAŞAK, Ali KURTSOY Department of Neurosurgery, Kayseri Training and Research Hospital, Kayseri, Turkey Department of Neurosurgery, Şevket Yılmaz Training and Research Hospital, Bursa, Turkey Department of Neurosurgery, Faculty of Medicine, Erciyes University, Kayseri, Turkey Department of Neurosurgery, Faculty of Medic...

full text

(Hydroxy)-chloroquine retinal toxicity: two case reports and safety guidelines.

Retinal toxicity as a result of antimalarial therapy has been reported for many years. Retinopathy may be divided into reversible premaculopathy and irreversible true retinopathy. Risk factors for the development of toxicity are daily dosage related to body weight, total drug dosage and the specific drug used. The daily dosage of chloroquine should not exceed 4 mg/kg lean body weight a day. Exc...

full text

My Resources

Save resource for easier access later

Save to my library Already added to my library

{@ msg_add @}


Journal title

volume 8  issue 2

pages  0- 0

publication date 2022-04

By following a journal you will be notified via email when a new issue of this journal is published.

Keywords

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023