Promoted Preparation of Aminophosphonate and Functionalized Coumarins Derivatives as Key Constituent of Many Pharmaceutical Compounds

The reaction  between  trialkyl  phosphites  with  dialkyl  actylenedicarboxylates  in the presence of 2-hydroxyquinoline  (2-quinolinol)  leads  to  β-aminophsphonates derivatives  which  they  have  many applications in medicinal chemistry. When the reaction was performed by triphenylphosphite, a new pyrano quinoline  compounds  were obtained  in  fairly  good  yields. These  compounds also  provide biologically interesting.  All roducts  were  established  by  IR,  NMR  (1H,13C and31P),mass spectroscopy and elemental analysis.