Preventive and Therapeutic Vaccines against Human Papillomaviruses Associated Cervical Cancers
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Abstract:
Cervical cancer is, globally known to be, one of the most common cancers among women especially indeveloping countries. More than 90% of cervical cancers are associated with high-risk humanpapillomaviruses (HPVs) particularly HPV types 16 and 18. Two major strategies have been developed forprevention and treatment of cervical cancer and other HPV-associated malignancies; the first one is based onHPV virus-like particles (VLPs) containing HPV structural proteins. VLP based vaccines can inducegenotype specific virus neutralizing antibodies for preventing HPV infections. The other strategy is based onHPV early genes especially E6 and E7 for eliminating the established HPV infections; therefore they areclassified as HPV therapeutic vaccines. This article reviews the preventive and therapeutic vaccines againstHPV infections and cervical cancer.
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preventive and therapeutic vaccines against human papillomaviruses associated cervical cancers
cervical cancer is, globally known to be, one of the most common cancers among women especially indeveloping countries. more than 90% of cervical cancers are associated with high-risk humanpapillomaviruses (hpvs) particularly hpv types 16 and 18. two major strategies have been developed forprevention and treatment of cervical cancer and other hpv-associated malignancies; the first one is based ...
full textTherapeutic Vaccines Against Human Papillomavirus and Cervical Cancer
Cervical cancer and its precursor intra-epithelial lesions are linked to infection by a subset of so-called "highrisk" human papillomavirus types, which are estimated to infect nearly four hundred million women worldwide. Two prophylactic vaccines have been commercialized recently targeting HPV16 and 18, the most prevalent viral types found in cervical cancer, which operate through induction of...
full textHuman papillomavirus-associated cervical cancer: Prophylactic and therapeutic vaccines
Abbreviations: Adeno-associated virus, (AAV); bacilli Calmette-Guerin, (BCG); base pairs, (bp); cottontail rabbit papilloma virus, (CRPV); E6-associated protein, (E6-AP); epidermal growth factor receptor, (EGFR); histone deacetylases, (HDAC); human papillomavirus, (HPV); inverted terminal repeats, (ITRs); listerolysin O, (LLO); of lysosome-associated membrane protein, (LAMP); open reading frame...
full textCurrent and Next-generation Vaccines against Human Papillomaviruses
Human papillomaviruses (HPVs) infect the squamous epithelium, and cause skin warts, genital warts and cancers, including uterine cervical cancer. Amongst the enormously diverse types of HPVs, HPV16 and HPV18 are most prevalent and responsible for approximately 70% of cervical cancer cases. Current preventive HPV vaccines contain virus-like particles which are composed of L1 major capsid protein...
full textHuman papillomaviruses and cervical cancer
The central causal role of the human papillomaviruses (HPV) in cervical cancer has been well established. The association is present in almost all cases of cervical cancer in the world. The ability of HPV oncogenes to interact with host cell cycle and growth regulators, as well as to elude the immune response and protect infected cells from apoptosis, can promote the persistence of the infectio...
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Journal title
volume 15 issue 1
pages 585- 601
publication date 2012-01-01
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